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Studying Dynamics of Monocyte HIV RNA Persistence and the Interface with CNS Outcomes during Acute HIV Infection

Award Number: F31AI145627
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 06/08/2022

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Studying Dynamics of Monocyte HIV RNA Persistence and the Interface with CNS Outcomes during Acute HIV Infection - The goal of my work is to elucidate the role of latent HIV infection in myeloid cells as an approach to better understand myeloid immune dysfunction, inflammation and early stages of cognitive decline during acute HIV infection (AHI). Our preliminary data show monocyte associated HIV DNA data are consistent with the hypothesis that monocytes harbor HIV DNA and RNA during early infection. Expanding on our on-going studies evaluating monocyte associated HIV DNA, I intend to investigate monocyte HIV RNA burden in blood and CSF prior to and post-ART intervention and in the context of adjunctive anti-inflammatory therapy during AHI. The RV408/SEARCH018 cohort provides access to conducting my proposed single cell assessments for monocyte phenotype and single cell RNA sequencing. Results from my aims will form the basis for defining early HIV RNA transcriptional activity to our presently limited understanding of monocyte associated HIV RNA burden.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$11,556 )
2024	2021	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Allergy and Infectious Diseases Research	000	3	6/18/2024	NON-COMPETING CONTINUATION	-$11,556
														Subtotal = -$11,556

Issue Date FY: 2023 ( Subtotal = -$19,550 )
2023	2021	UNIVERSITY OF HAWAII	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Allergy and Infectious Diseases Research	000	3	6/20/2023	NON-COMPETING CONTINUATION	-$19,550
														Subtotal = -$19,550

Issue Date FY: 2021 ( Subtotal = $30,036 )
2021	2021	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Allergy and Infectious Diseases Research	000	3	8/13/2021	NON-COMPETING CONTINUATION	$30,036
														Subtotal = $30,036

Issue Date FY: 2020 ( Subtotal = $29,520 )
2020	2020	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Allergy and Infectious Diseases Research	000	2	8/5/2020	NON-COMPETING CONTINUATION	$29,520
														Subtotal = $29,520

Issue Date FY: 2019 ( Subtotal = $29,016 )
2019	2019	UNIVERSITY OF HAWAII SYSTEMS	2425 CAMPUS RD SINCLAIR RM 1	HONOLULU	HI	96822	HONOLULU	USA	Allergy and Infectious Diseases Research	000	1	8/1/2019	NEW	$29,016
														Subtotal = $29,016

Grand Total All Awards = $57,466

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Studying Dynamics of Monocyte HIV RNA Persistence and the Interface with CNS Outcomes during Acute HIV Infection

Award Number: F31AI145627

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 06/08/2022

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