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A Comparative Study of M. tuberculosis and M. bovis BCG of T cell responses

Award Number: F31AI094957
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/01/2014
PERIOD OF PERFORMANCE END DATE: 02/28/2016

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A Comparative Study of M. tuberculosis and M. bovis BCG of T cell responses - On October 29, 2012, the NYU Langone Medical Center was hit by the Superstorm Sandy, which caused significant damages to the facilities used to conduct my research. Hurricane Sandy caused storm surges that exceeded what our facilities could withstand, leading to significant flooding. The repercussions of this flooding led to mechanical, electrical, and plumbing damages in many of the research buildings at NYU. These damages led to immediate loss of experiments and reagents but have also long-term delays in the completion of this project. In the wake of Hurricane Sandy, access to all research buildings was limited due to health and safety issues. Smilow Research Building, our main laboratory location, had no power for a week post-Sandy, which meant that freezers and refrigerators containing reagents we use routinely for experimentation were lost. Full-power and unrestricted access to the Smilow Research Building was not restored until one month post-Sandy. After the re-opening of Smilow, an additional 2 months of our time was dedicated to cataloging research losses and purchasing new reagents for experimentation. The Berg Building, which houses our Biosafety Level 3 (ABSL3) facility, remains without power. This facility housed animals infected with M. tuberculosis (M.tb) and is where we processed all infected samples prior to the storm. All infectious samples from on-going experiments were stored in refrigerators and freezers within the ABSL3 facility. We were able to save bacterial strains stored within our -80C freezer by supplying it with dry ice, however many other samples from on-going experiments could not be saved. The loss of these experimental samples is equal to a loss of three 6-week experiments. Work with the infected animals of the ongoing experiments at that time was significantly delayed in the absence of a proper ABSL3 facility and prevented the analysis of samples at key time points during infection. The ABSL3 located in Berg remains without power, ventilation, running water, or elevator access; the reopening of this facility is projected to be in September of this year, which will make it nearly a year post-Sandy, that this facility has been shut down. In the meantime we have made use of a second BSL3 facility within the Smilow Research Building, which is now operational on a limited basis to resume M. tuberculosis experiments. This facility was suited for in vitro work, with one Tissue Culture (TC) hood available for TB work, which was a huge bottleneck for progress, since amongst the TB labs at NYU we went from 4 available TC hoods to 1 available hood for experimentation. With the exception of Aim 1 of this project, all other proposed experiments for this award require mouse infections with M. tuberculosis. In April 2013, 6 months post-Sandy, we were able to expand to 2 TC hoods (shared by 15 people), it was also at this time that we were able to relocate the aerosol unit from our ABSL3 in the Berg Building to this Smilow BSL3. A satellite mouse housing facility has been built to accommodate our need for infected animal housing post-Sandy. To-date, we are ~20% operational post-Sandy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$3,307 )
2019	2014	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	HHS Programs for Disaster Relief Appropriations Act - Non Construction	000	3	1/15/2019	SUPPLEMENT FOR EXPANSION	-$3,307
														Subtotal = -$3,307

Issue Date FY: 2014 ( Subtotal = $42,676 )
2014	2014	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	HHS Programs for Disaster Relief Appropriations Act - Non Construction	001	3	1/16/2014	SUPPLEMENT FOR EXPANSION	$42,232
2014	2014	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	HHS Programs for Disaster Relief Appropriations Act - Non Construction	002	3	2/24/2014	SUPPLEMENT FOR EXPANSION	$0
2014	2014	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	HHS Programs for Disaster Relief Appropriations Act - Non Construction	003	3	2/25/2014	SUPPLEMENT FOR EXPANSION	$444
2014	2013	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	1/16/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $42,676

Issue Date FY: 2013 ( Subtotal = $42,232 )
2013	2013	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	1/17/2013	NON-COMPETING CONTINUATION	$42,232
2013	2013	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	001	3	1/16/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $42,232

Issue Date FY: 2012 ( Subtotal = $42,232 )
2012	2012	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	2	2/27/2012	NON-COMPETING CONTINUATION	$42,232
														Subtotal = $42,232

Issue Date FY: 2011 ( Subtotal = $41,800 )
2011	2011	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	002	1	2/22/2011	NEW	$0
2011	2011	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	004	1	4/28/2011	NEW	$420
2011	2011	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	003	1	3/4/2011	NEW	$0
2011	2011	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	001	1	2/22/2011	NEW	$0
2011	2011	NEW YORK UNIVERSITY MEDICAL CENTER	550 1ST AVE, SC-2 KIPS BAY BG	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	1	2/1/2011	NEW	$41,380
														Subtotal = $41,800

Grand Total All Awards = $165,633

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A Comparative Study of M. tuberculosis and M. bovis BCG of T cell responses

Award Number: F31AI094957

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/01/2014

PERIOD OF PERFORMANCE END DATE: 02/28/2016

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