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Advancing a novel performance-based test of cognition and daily functioning towards screening for preclinical Alzheimer's disease

Award Number: F31AG099691
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/25/2027
PERIOD OF PERFORMANCE END DATE: 02/24/2028

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Advancing a novel performance-based test of cognition and daily functioning towards screening for preclinical Alzheimer's disease - PROJECT SUMMARY Alzheimer’s disease (AD) clinical trials are costly and time consuming, with per-participant screening costs commonly being the most expensive factor. Preclinical AD trials in asymptomatic individuals are particularly costly, with typical screen-failure rates of 88% and running for ~8 years, much higher and longer than clinical trials in other therapeutic areas. Thus, there is an urgent need for low-cost enrichment tools that can improve the efficiency of preclinical AD trials by screening potential participants for eligibility and likelihood of natural decline during trial enrollment (~18-24 months). However, current enrichment strategies like blood-based biomarkers do not reliably predict an individual’s cognitive and functional trajectory in the short term. One enrichment solution that has potential currently is the Brief Evaluation of Cognition and Daily Function (BEan), an objective performance-based test that uses household items to assess the integration of cognition into daily activities that takes less than five minutes. The long-term goal of this project is to merge the PI’s experience in engineering, cellular neuroscience, and human subjects experimentation with her interest in AD-focused research to enhance her career in understanding preclinical AD from a neuroepidemiological context. The overall objective of this application is to leverage existing data from longitudinal studies in asymptomatic adults ages 50+ within the Arizona Alzheimer’s Consortium to determine the neurobiological mechanisms underpinning the BEan and its specificity to AD, and to establish normative values for change in BEan scores over time. The central hypothesis is that the BEan will be sensitive and specific to AD pathology with minimal annual change. Since the BEan is quick (<5 minutes) and costs less than $10 to assemble, the rationale for this proposed research offers an affordable and efficient means to enrich preclinical AD trials. There are three independent aims within this proposal. Aim 1 will examine the associations between the BEan and core AD plasma biomarkers. Aim 2 will examine the associations between the BEan and core AD magnetic resonance imaging (MRI) markers. Aim 3 will establish normative amounts of reliable change in BEan scores over time. If successful, this project will advance this novel, performance-based screening tool as an enrichment strategy for AD clinical trials that will minimize trial cost and duration. This project will also develop the PI’s career in functional motor behavior, biostatistics and bioinformatics, and neuropsychology and reliable change within an AD context. Together, the proposed research and training activities provide a foundation towards the PI’s independent research career dedicated to studying how motor behavior can uncover insights into AD and related dementias.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	ARIZONA STATE UNIVERSITY	1475 N SCOTTSDALE RD STE 200	SCOTTSDALE	AZ	85257	MARICOPA	USA	Aging Research	000	1	8/25/2026	NEW	$50,114
														Subtotal = $50,114

Grand Total All Awards = $50,114

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Advancing a novel performance-based test of cognition and daily functioning towards screening for preclinical Alzheimer's disease

Award Number: F31AG099691

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/25/2027

PERIOD OF PERFORMANCE END DATE: 02/24/2028

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