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Sleep Characteristics in Children and Adolescents with Prenatal Alcohol Exposure

Award Number: F31AA031907
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/01/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Sleep Characteristics in Children and Adolescents with Prenatal Alcohol Exposure - Project Summary/Abstract Prenatal alcohol exposure (PAE) can lead to a wide range of physical, behavioral, and cognitive impairments referred to as fetal alcohol spectrum disorders (FASD). The estimated prevalence of FASD is 2-5% of children in the United States, making PAE one of the leading preventable causes of neurodevelopmental disorders. Despite the known damaging effects of PAE, 10% of women in the United States report consuming alcohol during pregnancy; thus, PAE is a major public health concern. Additionally, caregivers of children with PAE often report their child has sleep problems; yet, relatively little is known of sleep quality in this population, whether alterations in circadian rhythmicity contribute to sleep problems, and how sleep quality changes as individuals with PAE enter adolescence. We recently found that children with FASD display greater night-to- night variability in sleep duration, and this night-to-night variability is more pronounced in older children. Further, we found that PAE disturbs expression levels of core clock genes that may be associated with altered sleep cycles and behavioral problems observed in children with PAE. Thus, PAE may greatly impact an individual’s circadian rhythmicity, which plays a role in an individual’s physiological, health, and behavioral functioning. Yet, no studies to date have examined circadian rhythmicity in this population and its relationship to sleep quality and behavior. This study will explore whether altered circadian rhythmicity is a biological mechanism that explains sleep disturbances in children and adolescents with PAE. Additionally, limited studies have explored age-related differences in sleep in individuals with FASD. Particularly, there is a dearth in research investigating whether sleep disturbances persist into adolescence, a critical developmental period marked by important psychophysiological changes in sleep behavior and architecture. This proposal will also examine sleep quality and circadian rhythmicity during adolescence. Moreover, we will investigate whether these behaviors affect cognitive and behavioral functioning in adolescents with PAE, as we have seen that sleep quality mediates aspects of neurobehavioral functioning in children with PAE, including cognitive, emotional, and behavioral functioning. If sleep problems contribute to difficulties in domains outside of sleep, interventions that target sleep could also improve cognitive and emotional functioning as well. Elucidation of the mechanisms by which PAE alters sleep and understanding how sleep and circadian rhythmicity change across development in individuals with PAE will allow us to develop effective interventions to improve quality of life of individuals with FASD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $39,689 )
2025	2025	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Alcohol Research Programs	000	2	7/24/2025	NON-COMPETING CONTINUATION	$39,689
														Subtotal = $39,689

Issue Date FY: 2024 ( Subtotal = $39,125 )
2024	2024	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Alcohol Research Programs	001	1	7/25/2024	NEW	$0
2024	2024	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Alcohol Research Programs	000	1	7/25/2024	NEW	$39,125
2024	2024	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Alcohol Research Programs	002	1	7/25/2024	NEW	$0
														Subtotal = $39,125

Grand Total All Awards = $78,814

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Sleep Characteristics in Children and Adolescents with Prenatal Alcohol Exposure

Award Number: F31AA031907

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/01/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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