Sunday, November 24, 2024 11/24/2024

Exploring differential biological and psychological effects of regular alcohol and cannabis use in humans

Award Number: F31AA030492
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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Project Summary/Abstract Cannabis is the most commonly used substance among individuals who consume alcohol, but there is conflicting evidence regarding the effects of cannabis on alcohol use and specific health outcomes. Furthermore, physiological responses to long-term and regular use of these substances differ substantially. The present study aims to investigate physiological and psychological differences across individuals with different patterns of alcohol and cannabis use (individuals who exclusively and regularly use cannabis-only, alcohol-only, and individuals who regularly use both alcohol and cannabis). The specific aims are to (1) investigate the effects of regular cannabis and alcohol consumption on the gut microbiome and intestinal permeability in the three groups, (2) examine baseline circulating levels of endocannabinoids and differences in relation to substance use patterns, and (3) explore trait depression and anxiety symptoms and diagnoses among the three groups with validated indices such as Beck’s depression and anxiety inventories. These aims will be tested through collection of fecal and blood samples, as well as administration of several psychological assessments and substance use questionnaires to individuals between the ages of 21-40 who regularly use alcohol or cannabis or a combination of both. The current proposal is innovative in its multi-faceted approach to examining the effects of alcohol and cannabis, and novel in its consideration of an endocannabinoid-microbiota-gut-brain axis. Structural equation modeling will be used to investigate the aims, with data from an advanced biostatistics pipeline for microbiome analysis. This proposal is designed to advance the candidate’s long-term goal of becoming an independent scientist with advanced methodological and statistical knowledge that can be applied to clinical treatment of substance use and mental health disorders. The training objectives are to (a) develop skills and knowledge to bridge physiological processes and human psychopathology/behavior (alcohol and substance use, depression and anxiety), (b) develop proficiency and applied expertise in human gut microbiome research and analysis, and (c) develop competency and applied expertise in cannabinoid and endocannabinoid system research (methodology and analysis). Foundational knowledge generated from this proposal will inform the candidate’s future research directions and grant applications. The training will enable the candidate to become an innovative, skilled researcher capable of utilizing advanced methods and statistics to conduct rigorous research on integrative psycho-physiological processes and how they are impacted by alcohol and cannabis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $40,068 )
2024	2024	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Alcohol Research Programs	000	2	11/1/2023	NON-COMPETING CONTINUATION	$38,288
2024	2024	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Alcohol Research Programs	001	2	5/17/2024	NON-COMPETING CONTINUATION	$1,780
														Subtotal = $40,068

Issue Date FY: 2022 ( Subtotal = $37,346 )
2022	2022	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Alcohol Research Programs	001	1	9/1/2022	NEW	$0
2022	2022	COLORADO STATE UNIVERSITY	601 S HOWES ST	FORT COLLINS	CO	80521	LARIMER	USA	Alcohol Research Programs	000	1	9/1/2022	NEW	$37,346
														Subtotal = $37,346

Grand Total All Awards = $77,414

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Exploring differential biological and psychological effects of regular alcohol and cannabis use in humans

Award Number: F31AA030492

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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