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Between- and Within-Person Effects of Alcohol and Cannabis Co-Use on Subjective Alcohol Response and Problem Drinking

Award Number: F31AA030167
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 06/01/2022
PERIOD OF PERFORMANCE END DATE: 08/14/2023

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Between- and Within-Person Effects of Alcohol and Cannabis Co-Use on Subjective Alcohol Response and Problem Drinking - Project Abstract: The proposed fellowship seeks to identify whether subjective alcohol response (i.e., acute affective and intoxicating effects) serve as both between-person and within-person mechanisms of risk through which alcohol and cannabis co-use is related to heavier drinking and negative consequences. The applicant's long- term career goal is to obtain a tenure-track faculty position with a research program focused on the dynamic interplay among co-use, subjective response, and impulsivity as predictors of problem drinking. This fellowship will enable the applicant to gain expertise in subjective response to co-use, advanced quantitative analyses, as well as Ecological Momentary Assessment (EMA) data management and organization. This fellowship will also enable the applicant to develop and strengthen fruitful collaborations with leaders in the field of co-use, subjective response, and EMA methods. The current training plan features a highly skilled mentoring team with expertise in subjective alcohol response (Dr. William Corbin), advanced quantitative analyses (Dr. Kevin Grimm), subjective response to cannabis/co-use (Dr. Jane Metrik), and EMA methods of co-use (Drs. Christine Lee and Timothy Trull). The proposed project will use data from an ongoing EMA study that captures event- level data on subjective response to moments of co-use (vs. alcohol-only use), as well as same-night drinking quantity and negative consequences via a novel phone application (TigerAware). The proposed study will test 1) whether co-users (vs. alcohol-only users) endorse heightened between-person levels of subjective response (i.e., acute affective and intoxicating effects), 2) whether event-level co-use (vs. alcohol-only use) is associated with heightened within-person levels of subjective response, and 3) whether subjective response mediates the within-person effect of event-level co-use (vs alcohol-only use) on heavier drinking and negative consequences aggregated to the day-level. Participants (Current N=115; Target N=130) will come from a 21-day EMA study, in which they were asked to fill out a morning report, two afternoon reports, and three nightly reports. Participants were asked to initiate a drink report when drinking, which had follow-up assessments that replaced concurrent random reports at that time. Co-use of alcohol and cannabis was assessed during drink reports, acute subjective response was assessed during drink reports, and past-night drinking quantity and negative consequences were assessed during next-day morning reports. The proposed study will be the first to test both between-person and within-person differences in subjective response based upon co-use. It will also be the first to differentiate co-use “subjective intoxication” from several subjective response domains, which is vital to understand which acute effects are enhanced or exacerbated by co-use. Findings will inform brief interventions by better understanding 1) between-person risk factors for alcohol misuse to tailor via broad-level interventions, and 2) within-person risk factors to target via just-in-time interventions seeking to reduce alcohol misuse on riskier (i.e., co-use) days.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$17,126 )
2024	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Alcohol Research Programs	000	2	6/24/2024	NON-COMPETING CONTINUATION	-$17,126
														Subtotal = -$17,126

Issue Date FY: 2023 ( Subtotal = $22,480 )
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Alcohol Research Programs	002	2	8/31/2023	NON-COMPETING CONTINUATION	-$23,873
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Alcohol Research Programs	001	2	6/12/2023	NON-COMPETING CONTINUATION	$14,659
2023	2023	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Alcohol Research Programs	000	2	4/28/2023	NON-COMPETING CONTINUATION	$31,694
														Subtotal = $22,480

Issue Date FY: 2022 ( Subtotal = $45,411 )
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Alcohol Research Programs	002	1	5/24/2022	NEW	$0
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Alcohol Research Programs	001	1	5/24/2022	NEW	$716
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Alcohol Research Programs	003	1	6/30/2022	NEW	$4,973
2022	2022	ARIZONA STATE UNIVERSITY	660 S MILL AVE STE 312	TEMPE	AZ	85281	MARICOPA	USA	Alcohol Research Programs	000	1	3/9/2022	NEW	$39,722
														Subtotal = $45,411

Grand Total All Awards = $50,765

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Between- and Within-Person Effects of Alcohol and Cannabis Co-Use on Subjective Alcohol Response and Problem Drinking

Award Number: F31AA030167

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 06/01/2022

PERIOD OF PERFORMANCE END DATE: 08/14/2023

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