Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Anterior Cingulate Cortex to Dorsal Striatal Circuits in Compulsive-like Binge Alcohol Drinking

Award Number: F31AA029273
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/01/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2023

Group Awards By:

View Award Description

Anterior Cingulate Cortex to Dorsal Striatal Circuits in Compulsive-like Binge Alcohol Drinking - Project Summary/Abstract This project proposes to investigate the underlying neural mechanisms within the dorsal striatum driving the development and maintenance of compulsive-like binge-drinking, or consumption of alcohol despite known negative consequences, using chemogenetics and awake-and-behaving electrophysiology in male and female C57BL/6J mice. Despite the established functional relationship of the prefrontal cortex inputs into the dorsomedial striatum (DMS) for goal directed behaviorally flexible alcohol drinking and the dorsolateral striatum (DLS) in compulsive behaviorally inflexible alcohol drinking, the circuit level shift in control of modulating the development of compulsive-like alcohol drinking has not been defined, which limits prevention and treatment of alcohol use disorder (AUD). The major hypotheses of this project are 1) the development and maintenance of compulsive-like alcohol drinking relies on DLS mechanisms of potentiation from anterior cingulate cortex (ACC) excitatory inputs which are facilitated by reduced ACC-DMS input and 2) that neuronal activity in the DMS and DLS will differ based on alcohol drinking history, bull all mice will increase activity in the DLS and compulsive- like mice will have greater DLS activity than DMS activity. The proposed project will assess the neural mechanisms underlying home cage compulsive-like binge-drinking using drinking-in-the-dark during chemogenetic inhibition from the ACC-DMS and ACC-DLS and through awake-and-behaving electrophysiology recordings in the DS during compulsive-like alcohol drinking. The training plan for this project is curated in an ideal research environment, engaging collaboration between both Indiana University – Purdue University Indianapolis and the Indiana Alcohol Research Center to provide training in cutting edge neuroscience techniques, professional development, and research ethics that will facilitate my career as an independent scientist. The specific research hypotheses are 1) ablation of the excitatory projections from the ACC to the DMS will cause alcohol naïve mice to develop and alcohol history mice to increase compulsive-like alcohol drinking across drinking sessions. 2) Ablation of the excitatory projections from the ACC to the DLS will cause alcohol naïve mice to prevent development and alcohol history mice to attenuate compulsive-like alcohol drinking across drinking sessions. 3) Alcohol naïve and alcohol history mice will differ in their pattern of neuronal activity, with relatively increased activity in the DLS and relatively decreased activity in the DMS across drinking sessions in association with a compulsive-like alcohol drinking phenotype. Completion of the proposed work will elucidate understanding of the mechanisms and neural circuits underlying the development and maintenance of compulsive-like alcohol drinking and will serve to inform researchers in the field of addiction neuroscience, leading to increased understanding and ultimately improved prevention and treatment of AUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$15,969 )
2025	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	2	10/23/2024	NON-COMPETING CONTINUATION	-$15,969
														Subtotal = -$15,969

Issue Date FY: 2024 ( Subtotal = -$4,524 )
2024	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	2	1/5/2024	NON-COMPETING CONTINUATION	-$4,524
														Subtotal = -$4,524

Issue Date FY: 2023 ( Subtotal = $49,098 )
2023	2023	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	2	2/24/2023	NON-COMPETING CONTINUATION	$49,098
														Subtotal = $49,098

Issue Date FY: 2021 ( Subtotal = $44,940 )
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	001	1	9/7/2021	NEW	$0
2021	2021	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Alcohol Research Programs	000	1	9/7/2021	NEW	$44,940
														Subtotal = $44,940

Grand Total All Awards = $73,545

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Anterior Cingulate Cortex to Dorsal Striatal Circuits in Compulsive-like Binge Alcohol Drinking

Award Number: F31AA029273

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/01/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2023

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer