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Rare structural genomic variants in schizophrenia

Award Number: F30MH085467
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/01/2008
PERIOD OF PERFORMANCE END DATE: 11/30/2012

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Rare structural genomic variants in schizophrenia - DESCRIPTION (provided by applicant): Schizophrenia is a debilitating psychiatric illness that renders enormous individual, societal and public health burdens. The goal of my project is to use copy number variant (CNV) analysis as a gateway to gene discovery for schizophrenia. As my dissertation project, I propose to identify a potential disease-causing gene, by CNV analysis, then to experimentally characterize its variation in schizophrenia cases and controls. My proposed experimental approach is based on the hypothesis is that many different individually rare, deleterious mutations in many different genes contribute to the illness. Our recently published data supports this approach, and the role of rare large effect mutations in schizophrenia. My project will involve three steps. First, I will characterize rare genomic deletions and duplications (CNVs) that arise in persons with schizophrenia but not in healthy persons. I will select candidates from the genes impacted by these events, prioritizing those involved in neurodevelopmental processes and/or that have been previously implicated in neuropsychiatric illnesses. Second, I will resequence the exons and promoter regions of three promising candidate genes in unrelated persons with schizophrenia and in controls. I hypothesize that persons with schizophrenia are more likely than controls to harbor deleterious rare point mutations and frameshifts in these candidate genes. Third, based on the above results, I will select one promising candidate gene and experimentally characterize the functional impact of mutant alleles detected in cases. Identifying a gene related to schizophrenia has the potential to lead to improved diagnostic methods and treatments for individuals with the illness.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = $8,830 )
2017	2012	UNIVERSITY OF WASHINGTON	4333 BROOKLYN AVE NE	SEATTLE	WA	98195	KING	USA	Mental Health National Research Service Awards for Research Training	000	4	5/11/2017	NON-COMPETING CONTINUATION	$8,830
														Subtotal = $8,830

Issue Date FY: 2012 ( Subtotal = $32,422 )
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Mental Health National Research Service Awards for Research Training	001	4	3/9/2012	NON-COMPETING CONTINUATION	$432
2012	2012	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Mental Health National Research Service Awards for Research Training	000	4	11/29/2011	NON-COMPETING CONTINUATION	$31,990
														Subtotal = $32,422

Issue Date FY: 2011 ( Subtotal = $31,990 )
2011	2011	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Mental Health National Research Service Awards for Research Training	001	3	5/2/2011	NON-COMPETING CONTINUATION	$420
2011	2011	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Mental Health National Research Service Awards for Research Training	000	3	11/16/2010	NON-COMPETING CONTINUATION	$31,570
														Subtotal = $31,990

Issue Date FY: 2010 ( Subtotal = $31,570 )
2010	2010	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Mental Health National Research Service Awards for Research Training	001	2	1/28/2010	NON-COMPETING CONTINUATION	$204
2010	2010	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Mental Health National Research Service Awards for Research Training	000	2	11/19/2009	NON-COMPETING CONTINUATION	$31,366
														Subtotal = $31,570

Issue Date FY: 2008 ( Subtotal = $31,162 )
2008	2008	UNIVERSITY OF WASHINGTON	3917 UNIVERSITY WAY NE	SEATTLE	WA	98105	KING	USA	Mental Health National Research Service Awards for Research Training	000	1	9/29/2008	NEW	$31,162
														Subtotal = $31,162

Grand Total All Awards = $135,974

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Rare structural genomic variants in schizophrenia

Award Number: F30MH085467

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/01/2008

PERIOD OF PERFORMANCE END DATE: 11/30/2012

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