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Role of Estrogen Receptors and Neurohypophyseal Gene Expression in Vasopressin Release in a Model of Dilutional Hyponatremia

Award Number: F30HL158145
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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Purpose: Hyponatremia is the most common electrolyte disorder and in 2006 the cost of treating hyponatremia in the US was estimated to be $1.6-$3.6 billion per year. Inappropriate vasopressin secretion is the major cause of dilutional hyponatremia associated with liver and heart failure. Our previous studies have also shown that, in male BDL rats, BDNF-TrkB signaling in the SON contributes sustained AVP and copeptin (a clinical surrogate for AVP 1-3) release, and hyponatremia 4. However, little is known about the role of sex differences in hyponatremia5. Our data show that female BDL rats do not develop hyponatremia or increased AVP release6. Instead female BDL rats show increased release of oxytocin6 . Our findings also suggest that the effects of BDL on neurohypophyseal hormones may be sexually dimorphic. Our central hypothesis is that ER in the hypothalamo-neurohypophyseal system (HNS) contribute, at least in part, to sex differences seen in the BDL model of dilutional hyponatremia. Our hypotheses will be tested with the following Specific Aims: Aim 1 will define the contributions of estrogen receptors in hypothalamo-neurohypophyseal neurons to sex differences in a model of dilutional hyponatremia Aim 2 will determine differences in SON gene expression that may contribute to underlying sex differences in AVP release in a model of dilutional hyponatremia Benefit: These experiments will address an existing gap in our understanding of neurophypophyseal function and the pathogenesis of hyponatremia. The findings of these experiments could potentially alter the way that inappropriate vasopressin release is studied and conceptualized clinically.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $42,600 )
2024	2024	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Cardiovascular Diseases Research	000	3	1/5/2024	NON-COMPETING CONTINUATION	$42,600
														Subtotal = $42,600

Issue Date FY: 2023 ( Subtotal = $33,728 )
2023	2023	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Cardiovascular Diseases Research	001	2	3/14/2023	NON-COMPETING CONTINUATION	$942
2023	2023	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Cardiovascular Diseases Research	000	2	2/1/2023	NON-COMPETING CONTINUATION	$32,786
														Subtotal = $33,728

Issue Date FY: 2022 ( Subtotal = $33,186 )
2022	2022	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Cardiovascular Diseases Research	000	1	1/3/2022	NEW	$32,470
2022	2022	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Cardiovascular Diseases Research	003	1	8/16/2022	NEW	$0
2022	2022	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Cardiovascular Diseases Research	002	1	7/1/2022	NEW	$716
2022	2022	UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH	3500 CAMP BOWIE BLVD	FORT WORTH	TX	76107	TARRANT	USA	Cardiovascular Diseases Research	001	1	1/3/2022	NEW	$0
														Subtotal = $33,186

Grand Total All Awards = $109,514

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Role of Estrogen Receptors and Neurohypophyseal Gene Expression in Vasopressin Release in a Model of Dilutional Hyponatremia

Award Number: F30HL158145

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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