Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

The Impact of Thalamocortical Axon Refinement on the Development of the Prefrontal Cortex

Award Number: F30HD114477
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/18/2024
PERIOD OF PERFORMANCE END DATE: 03/17/2028

Group Awards By:

View Award Description

The Impact of Thalamocortical Axon Refinement on the Development of the Prefrontal Cortex - PROJECT SUMMARY / ABSTRACT Aberrant development of the prefrontal cortex (PFC), including the axonal connections it receives, are hallmarks of neurodevelopmental and neuropsychiatric disorders (NDDs). Foundational studies have shown that axons that project to the PFC, particularly from thalamic nuclei, influence PFC development and function. Notably, these axons are often disrupted in NDDs. We hypothesize that aberrant thalamocortical connectivity seen in these disorders results from abnormal axon pruning, which in turn leads to deficits in PFC maturation and function. To test this hypothesis, I will use a novel mouse model to inhibit axonal pruning in this circuit and determine its role in PFC development. I will use a combination of neural tracers, genomic, and molecular analysis to quantify axon pruning within the thalamocortical circuit to determine whether its disruption in our mouse models affects critical aspects of PFC development including lamination, neuronal number, interneuron migration, and electrical activity. This proposal, undertaken with the intellectual support of the Tri-Institutional research community and guidance of a mentorship team, will address a significant gap in understanding of how axon refinement regulates normal cortical development and can lead to cortical dysfunction seen in NDDs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $55,114 )
2026	2026	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Child Health and Human Development Extramural Research	001	3	3/24/2026	NON-COMPETING CONTINUATION	$576
2026	2026	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Child Health and Human Development Extramural Research	000	3	3/2/2026	NON-COMPETING CONTINUATION	$54,538
														Subtotal = $55,114

Issue Date FY: 2025 ( Subtotal = $52,976 )
2025	2025	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Child Health and Human Development Extramural Research	000	2	3/10/2025	NON-COMPETING CONTINUATION	$52,976
														Subtotal = $52,976

Issue Date FY: 2024 ( Subtotal = $51,696 )
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Child Health and Human Development Extramural Research	000	1	3/15/2024	NEW	$51,696
2024	2024	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Child Health and Human Development Extramural Research	001	1	3/15/2024	NEW	$0
														Subtotal = $51,696

Grand Total All Awards = $159,786

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The Impact of Thalamocortical Axon Refinement on the Development of the Prefrontal Cortex

Award Number: F30HD114477

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/18/2024

PERIOD OF PERFORMANCE END DATE: 03/17/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer