Tuesday, November 4, 2025 11/4/2025

Interleukin-13 in Central Regulation of Metabolism

Award Number: F30DK128884
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/16/2021
PERIOD OF PERFORMANCE END DATE: 08/15/2026

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Interleukin-13 in Central Regulation of Metabolism - PROJECT SUMMARY The immune system is an important and dynamic regulator of metabolism. In peripheral tissues, over-nutrition and obesity lead to marked changes in immune cell population, causing associated shifts in signaling and tissue function. While type I immunity is associated with the release of pro-inflammatory cytokines and insulin resistance, type II immunity has been shown to promote beige fat biogenesis, glucose homeostasis, and energy balance. In the brain, activation of the pro-inflammatory NF-kB signaling pathway can lead to hyperphagia and metabolic dysfunction. Whether activation of type II immune signaling pathways can restore energy balance and protect against obesity has not yet been investigated. IL-13 is a Th2 cytokine that signals through its cellular receptor IL-13R1. Whole body deletion of Il13ra1 causes obesity and loss of blood glucose homeostasis. Il13ra1 is expressed in the subtantia nigra and ventral tegmental area of the brain. Preliminary data show that specific deletion of Il13ra1 from the dopaminergic midbrain at least partially reproduces the metabolic phenotypes of the whole-body knockout. The substantia nigra and ventral tegmental area are the primary producers of dopamine in the CNS. Numerous studies have related central dopamine activity to energy balance. In this study, we will test the hypothesis that central IL-13 signals through its receptor in the dopaminergic midbrain to maintain energy balance. We will investigate the cellular and molecular mechanisms by which it does so. We will use both gain-of-function and loss-of-function genetic models to test our hypothesis. Knowledge from this study is expected to fill major gaps in our understanding of how the immune system interacts with the nervous system to coordinate metabolic regulation, and also to identify novel pathways in the CNS that modulate energy balance.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$7,056 )
2025	2024	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	6/3/2025	NON-COMPETING CONTINUATION	-$7,056
														Subtotal = -$7,056

Issue Date FY: 2024 ( Subtotal = $53,974 )
2024	2024	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/18/2024	NON-COMPETING CONTINUATION	$53,974
														Subtotal = $53,974

Issue Date FY: 2023 ( Subtotal = $43,290 )
2023	2023	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	7/11/2023	NON-COMPETING CONTINUATION	$43,290
														Subtotal = $43,290

Issue Date FY: 2022 ( Subtotal = $42,348 )
2022	2022	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/21/2022	NON-COMPETING CONTINUATION	$42,348
														Subtotal = $42,348

Issue Date FY: 2021 ( Subtotal = $41,632 )
2021	2021	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/10/2021	NEW	$41,632
2021	2021	TRUSTEES OF TUFTS COLLEGE	136 HARRISON AVE	BOSTON	MA	02111	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	8/10/2021	NEW	$0
														Subtotal = $41,632

Grand Total All Awards = $174,188

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Interleukin-13 in Central Regulation of Metabolism

Award Number: F30DK128884

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/16/2021

PERIOD OF PERFORMANCE END DATE: 08/15/2026

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