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Investigating the role of ELAVL1 as a post-transcriptional regulator of cranial neural crest development

Award Number: F30DE034639
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/15/2025
PERIOD OF PERFORMANCE END DATE: 08/14/2030

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Investigating the role of ELAVL1 as a post-transcriptional regulator of cranial neural crest development - PROJECT SUMMARY/ABSTRACT The neural crest (NC) is a multipotent stem cell population that is critical for normal craniofacial morphogenesis in vertebrates. During NC development, NC cells delaminate from the neural tube and migrate throughout the developing embryo. The cranial NC ultimately differentiates into various structures of the head and face, including the craniofacial skeleton and cranial sensory ganglia. For cranial NC cells to properly contribute to these structures, they must undergo an epithelial-to-mesenchymal transition (EMT), which allows these cells to migrate to their correct destinations. Perturbing one or more events of NC development results in structural craniofacial defects (e.g. cleft lip/palate) and abnormal trigeminal sensory innervation. Thus, a thorough understanding of cranial NC development is essential for identifying the etiology of craniofacial abnormalities. Recently, ELAVL1, a ubiquitous RNA-binding protein, was discovered to have critical regulatory roles in premigratory cranial NC to correctly time the onset of EMT. My preliminary findings suggest that ELAVL1 continues regulate cranial NC development following EMT, during cranial NC migration and subsequent cranial gangliogenesis. The goal of this Proposal is to characterize the role of ELAVL1 during cranial NC development and trigeminal gangliogenesis in the chick embryo. The findings of this study will advance our current understanding of the etiology of craniofacial anomalies, and more specifically, contribute basic scientific knowledge essential to understanding neurocristopathies, particularly those affecting somatosensory perception in the head and face.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $50,006 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Oral Diseases and Disorders Research	001	1	7/31/2025	NEW	$0
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Oral Diseases and Disorders Research	000	1	7/31/2025	NEW	$50,006
														Subtotal = $50,006

Grand Total All Awards = $50,006

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Investigating the role of ELAVL1 as a post-transcriptional regulator of cranial neural crest development

Award Number: F30DE034639

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/15/2025

PERIOD OF PERFORMANCE END DATE: 08/14/2030

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