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Lateral line sensory nerve guidance by a migrating cell collective

Award Number: F30DC023426
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/18/2025
PERIOD OF PERFORMANCE END DATE: 09/17/2029

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Lateral line sensory nerve guidance by a migrating cell collective - PROJECT SUMMARY The cochlear nerve, critical for hearing, relies on precise extension and connectivity during development. Cochlear nerve deficiency (CND) is a congenital malformation resulting in an absent or small cochlear nerve that leads to severe or profound hearing loss with permanent and detrimental effects on patient quality of life. To better understand CND pathophysiology, the mechanisms guiding cochlear nerve development must be understood. This project’s objective is to determine how the in vivo tissue environment impacts cochlear nerve development, using the zebrafish posterior lateral line nerve (pLLN) as a model. Similar to processes in the mammalian cochlea, the zebrafish pLLN extends alongside a migrating cell collective called the primordium. Our hypothesis is that secreted signals from the primordium contribute to the dynamics of adhesive signaling in pLLN development. These mechanisms will be investigated in zebrafish by integrating in vivo imaging of fluorescently labeled growth cones and primordium cells with genetic and experimental manipulations. In Aim 1, the role of specific adhesion molecules in the co-migration of the pLLN and primordium will be characterized. Aim 2 will examine how the location and timing of secreted cues impact pLLN extension and adhesion to the primordium. Lastly, Aim 3 will focus on mapping the progressions in gene expression of neurons forming the pLLN and the cells of the primordium over time as a way to evaluate the relative composition of intercellular signaling. These studies will clarify how adhesive and secreted cues cooperate to ensure robust pLLN development, offering insight into the developmental process of the cochlear nerve. Findings in these areas support the search for future therapeutic targets for CND. The described studies will be carried out under the direct mentorship of Dr. A. J. Hudspeth at The Rockefeller University within the supportive Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program environment. This fellowship constitutes an important career milestone for dual-degree students seeking to become independent investigators.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $54,538 )
2025	2025	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Research Related to Deafness and Communication Disorders	000	1	8/28/2025	NEW	$54,538
2025	2025	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Research Related to Deafness and Communication Disorders	001	1	8/28/2025	NEW	$0
2025	2025	WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY	575 LEXINGTON AVE FL 9	NEW YORK	NY	10022	NEW YORK	USA	Research Related to Deafness and Communication Disorders	002	1	9/25/2025	NEW	$0
														Subtotal = $54,538

Grand Total All Awards = $54,538

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Lateral line sensory nerve guidance by a migrating cell collective

Award Number: F30DC023426

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/18/2025

PERIOD OF PERFORMANCE END DATE: 09/17/2029

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