Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

How do pancreatic cancers remodel the tumor microenvironment to facilitate lethal metastatic outgrowth?

Award Number: F30CA306258
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 06/01/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2029

Group Awards By:

View Award Description

How do pancreatic cancers remodel the tumor microenvironment to facilitate lethal metastatic outgrowth? - PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) will become the second leading cause of US cancer-related deaths by the year 2030. Primary PDACs are encased within a densely fibrotic, nutrient poor (“desmoplastic”) stroma enriched with extracellular matrix, fibroblasts, and immune cells. In contrast, distant metastatic PDACs grow rapidly within a nutrient replete, loosely fibrotic stroma. The project objective is to define those fundamental TME differences and the fibroinflammatory signaling networks that govern them. The hypothesis is that PDACs remodel metastatic TMEs into a loosely fibrotic, immunodeficient stroma by suppressing pathways that yield fibroinflammatory cytokines. This hypothesis will be tested by two specific aims. Aim 1: Define key differences between primary and metastatic TMEs. Primary versus metastatic TMEs will be interrogated in humans and mice by (1) scoring key histopathological TME parameters across hundreds of primary and metastatic PDAC patient tissue samples; (2) quantifying tumor: stroma cell lineage abundances and communication networks using single cell RNA-seq datasets from PDAC patients; (3) flow cytometric sorting of cell lineages that comprise primary and metastatic TMEs in gold standard PDAC mouse models. The goal of Aim 1 is to discover TME determinants of divergent clinical behaviors and biological properties between primary tumors and distant metastases. Aim 2: Evaluate mechanisms that remodel metastatic TMEs. Genetic and pharmacological gain- and loss-of-function approaches will determine if (1) suppressing inflammatory signals depletes primary tumor fibroinflammatory cytokines from metastatic secretomes; (2) (re)- introducing those cytokines back into metastatic secretomes triggers a desmoplastic stromal response that restrains distant metastatic outgrowth; (3) depleting those cytokines from primary tumor secretomes remodels the desmoplastic stroma to facilitate distant metastatic spread. The goal of Aim 2 is to identify and functionally characterize primary tumor fibroinflammatory signals that are reprogrammed to facilitate distant metastasis. These studies will positively impact cancer research by concretely demonstrating how primary and metastatic TMEs diverge from one another and illustrating precise mechanisms that drive such divergences. The findings are expected to conceptually advance our understanding of cancer progression and rationally inform therapeutic strategies against primary and metastatic tumors, even within the same individual patient(s). This research will be conducted as part of an MD-PhD dual degree fellowship training plan at the University of Miami Miller School of Medicine Medical Scientist Training Program (UMMSM MSTP). The UMMSM MSTP training environment includes access to theoretical and technical instruction, physician scientist mentors, and state-of-the-art facilities for these studies. This proposal seeks to prepare for a training goal of becoming a physician scientist in the field of oncology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $55,114 )
2026	2026	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Cancer Research Manpower	000	1	5/19/2026	NEW	$55,114
2026	2026	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Cancer Research Manpower	001	1	5/19/2026	NEW	$0
														Subtotal = $55,114

Grand Total All Awards = $55,114

Top

All Categories

About

Search

Reports

Data Submission

Award Information

How do pancreatic cancers remodel the tumor microenvironment to facilitate lethal metastatic outgrowth?

Award Number: F30CA306258

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 06/01/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer