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Integration And Remodeling Of Bioprinted Skin In Full-Thickness Wound Healing

Award Number: F30AR074866
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 11/18/2019
PERIOD OF PERFORMANCE END DATE: 05/15/2023

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Integration And Remodeling Of Bioprinted Skin In Full-Thickness Wound Healing - PROJECT SUMMARY This project will provide multidisciplinary training for a dual-degree MD/PhD student in skin tissue engineering and burn reconstructive surgery, addressing an unmet clinical need for a skin substitute with full-regeneration potential. Burn injuries are a major clinical burden in the United States, with nearly 500,000 patients treated annually, a mortality rate of 4.9%, and an estimated cost of $2 billion per year. The standard of care for burn injuries includes autologous skin grafting, but these procedures require sufficient harvest sites that are scarce in patients with severe wounds. Tissue-engineered skin substitutes offer a promising alternative to skin grafts. However, current prototypes contain only up to two cell types; lack sweat and sebaceous glands, hair follicles, and pigmentation; and may not stimulate revascularization and innervation. Since the ultimate goal of a skin graft is to regenerate authentic anatomy and physiology of native skin, there is an immense need to develop bioengineered skin with more cell types and full regeneration potential. To meet the need for bioengineered skin, bioprinting techniques have been developed to more accurately engineer tissue substitutes with appropriate 3D structural organization. This proposal will test the hypothesis that a 3D bioprinted skin graft will support regeneration of native-like skin in full-thickness wounds in vivo, similar to skin autografts. To test this hypothesis, the fellowship applicant has proposed three Specific Aims. Aim 1 will delineate how bioprinted skin accelerates epidermal barrier formation in vivo. This aim will provide the applicant with training in digital planimetry analysis to measure rates of wound closure, and NOVATM dermal phase meter analysis to measure the extent of re-epithelialization over time. Aim 2 will explore how neovascularization occurs in bioprinted skin in vivo and will require competence qrtPCR to measure endothelial growth factors compared with IHC stained capillaries per mm2. Aim 3 will investigate how melanocyte migration impacts bioprinted skin pigmentation. This will require immunohistochemical staining to determine mouse vs. human tissue formation, hair follicle formation, and melanin production. The applicant has assembled a multidisciplinary team of sponsors, co- sponsors, contributors, and consultants with expertise in regenerative medicine, ECM imaging, biomaterials science, wound healing, dermatology, and burn reconstructive surgery. They have established a training plan with (1) Mentorship Meetings, (2) Coursework, (3) Research Training, and (4) Clinical Training that will allow the student to develop both technically and conceptually towards becoming an independent skin tissue engineer. This novel approach to treatment of full-thickness wounds, conducted at a world-class institute, will serve as a basis for the student's training, and allow this promising applicant to develop as a physician- scientist poised to address future deficits in burn reconstructive surgery through skin tissue engineering.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$53,670 )
2025	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	4	10/23/2024	NON-COMPETING CONTINUATION	-$40,818
2025	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	10/23/2024	NON-COMPETING CONTINUATION	-$12,852
														Subtotal = -$53,670

Issue Date FY: 2024 ( Subtotal = -$13,434 )
2024	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	9/13/2024	NON-COMPETING CONTINUATION	-$13,434
														Subtotal = -$13,434

Issue Date FY: 2023 ( Subtotal = $54,252 )
2023	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	11/23/2022	NON-COMPETING CONTINUATION	$53,536
2023	2023	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	4	2/28/2023	NON-COMPETING CONTINUATION	$716
														Subtotal = $54,252

Issue Date FY: 2022 ( Subtotal = $53,536 )
2022	2022	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	11/12/2021	NON-COMPETING CONTINUATION	$53,536
														Subtotal = $53,536

Issue Date FY: 2021 ( Subtotal = $53,536 )
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	12/8/2020	NON-COMPETING CONTINUATION	$50,520
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	003	2	8/27/2021	SUPPLEMENT FOR EXPANSION	$2,500
2021	2021	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	002	2	2/5/2021	NON-COMPETING CONTINUATION	$516
2021	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	12/18/2020	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $53,536

Issue Date FY: 2020 ( Subtotal = $50,016 )
2020	2020	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/18/2020	SUPPLEMENT FOR EXPANSION	$50,016
														Subtotal = $50,016

Issue Date FY: 2019 ( Subtotal = $50,016 )
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	8/2/2019	NEW	$0
2019	2019	WAKE FOREST UNIVERSITY HEALTH SCIENCES	MEDICAL CENTER BLVD	WINSTON SALEM	NC	27157	FORSYTH	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	8/2/2019	NEW	$50,016
														Subtotal = $50,016

Grand Total All Awards = $194,252

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Integration And Remodeling Of Bioprinted Skin In Full-Thickness Wound Healing

Award Number: F30AR074866

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 11/18/2019

PERIOD OF PERFORMANCE END DATE: 05/15/2023

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