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Defining the Proviral Role of Estrogen in Gammaherpesvirus Infection

Award Number: F30AI197750
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/05/2026
PERIOD OF PERFORMANCE END DATE: 08/04/2031

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Defining the Proviral Role of Estrogen in Gammaherpesvirus Infection - Project Summary/Abstract Human gammaherpesviruses, such as Epstein-Barr Virus (EBV), establish lifelong infections in >95% of the adult human population worldwide and are responsible for driving a number of cancers and autoimmune disease. Mechanisms underlying EBV-driven cancer and autoimmune disease remain poorly understood. One understudied host process involved in other acute and chronic viral infections is estrogen signaling; however, its role in gammaherpesvirus infection remains unknown. This proposal will define the extent to which estrogen signaling affects gammaherpesvirus infection. Gammaherpesviruses are highly species specific which makes studying natural EBV infection difficult. Therefore, we utilize murine gammaherpesvirus 68 (MHV68) which is a natural rodent pathogen that is genetically and biologically similar to human gammaherpesviruses and shares many of their pathogenic strategies and disease outcomes. Using the MHV68 system and my preliminary data, the proposed studies test the hypothesis that estrogen receptor signaling promotes lytic gammaherpesvirus replication through induction of viral genes in a ligand-dependent manner and supports chronic infection by expanding the germinal center response and increasing viral reactivation. Through this proposed multidisciplinary project, I will develop expertise in the fields of virology, immunology, and cell biology. I will also build important skills in mouse genetics and pharmacology. This formative experience through the Medical College of Wisconsin Medical Scientist Training Program will help me build creativity, critical thinking, and an intuition for science. Completing my proposed research training plan will promote my development into a well-rounded independent physician-scientist.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $52,227 )
2026	2026	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Allergy and Infectious Diseases Research	001	1	8/5/2026	NEW	$0
2026	2026	THE MEDICAL COLLEGE OF WISCONSIN, INC.	8701 WATERTOWN PLANK RD	MILWAUKEE	WI	53226	MILWAUKEE	USA	Allergy and Infectious Diseases Research	000	1	8/5/2026	NEW	$52,227
														Subtotal = $52,227

Grand Total All Awards = $52,227

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Defining the Proviral Role of Estrogen in Gammaherpesvirus Infection

Award Number: F30AI197750

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/05/2026

PERIOD OF PERFORMANCE END DATE: 08/04/2031

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