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CHARACTERIZING THE ROLE OF CARHSP1 IN THE AGING BRAIN AND ALZHEIMER'S DISEASE

Award Number: F30AG099329
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/25/2026
PERIOD OF PERFORMANCE END DATE: 12/24/2027

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CHARACTERIZING THE ROLE OF CARHSP1 IN THE AGING BRAIN AND ALZHEIMER'S DISEASE - ABSTRACT Despite extensive genetic and proteomic studies in Alzheimer’s disease (AD), the functional impact of disease- associated variants remains poorly understood. Proteome-wide association studies (PWAS) have identified variants in Calcium-Regulated Heat Stable Protein 1 (CARHSP1) that are significantly associated with AD. Furthermore, even outside of these mutations, increased CARHSP1 protein and RNA levels are observed in AD brains, indicating wide-spread dysregulation in disease. CARHSP1 is an RNA-binding protein that localizes to stress granules and interacts with inflammatory and metabolic pathways. However, its role in neuronal function and neurodegeneration remains undefined. In Drosophila, loss of CARHSP1 homolog, CG9705, alters synaptic activity and dendritic morphology. These findings indicate that CG9705 is required for normal neuronal function, independent of pathological stressors. Furthermore, CG9705 knockdown in tauopathy models ameliorates neurodegenerative phenotypes, while CARHSP1 overexpression exacerbates tau-induced neurotoxicity, suggesting that CARHSP1 plays a pathogenic role in AD. I hypothesize that CARHSP1 overexpression exacerbates tau-mediated neurotoxicity through dysregulated stress responses. To test this, Aim 1 will define the role of CARHSP1/CG9705 in normal neuronal function by characterizing phenotypes in loss- and gain-of-function Drosophila models. Aim 2 will identify genetic interactions that mediate CARHSP1-induced toxicity by testing known CARHSP1-associated pathways. Aim 3 will assess whether Carhsp1 loss mitigates AD progression in mammalian models using tau pathology and inflammatory markers. These studies will provide critical insight into RNA-binding proteins in neurodegeneration and establish CARHSP1 as a potential therapeutic target. This research, combined with structured training in neurogenetics and disease modeling, will equip me with expertise to bridge basic neuroscience with clinical translation as a physician scientist studying neurodegenerative disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,526 )
2026	2026	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Aging Research	000	1	6/30/2026	NEW	$50,526
														Subtotal = $50,526

Grand Total All Awards = $50,526

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CHARACTERIZING THE ROLE OF CARHSP1 IN THE AGING BRAIN AND ALZHEIMER'S DISEASE

Award Number: F30AG099329

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/25/2026

PERIOD OF PERFORMANCE END DATE: 12/24/2027

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