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ROLE OF UNCOUPLING PROTEIN-2 IN ALCOHOLIC CARDIOMYOPATHY

Award Number: F30AA015004
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/01/2008
PERIOD OF PERFORMANCE END DATE: 06/30/2008

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ROLE OF UNCOUPLING PROTEIN-2 IN ALCOHOLIC CARDIOMYOPATHY - DESCRIPTION (provided by applicant): Alcohol is a major public health concern in the United States due to the various well-documented pathological conditions associated with its use and abuse. Alcohol-induced heart disease is responsible for significant amount of morbidity and mortality in alcoholics, however, the understanding of many of the underlying molecular mechanisms remains elusive. The goal of this study is to test the hypotheses that 1) uncoupling protein-2 (UCP2) expression and activity has direct consequences which contribute to decreased myocardial contractility and the development of heart failure in alcoholic cardiomyopathy (ACM), 2) oxidative damage due to generation of excess reactive oxygen species (ROS) contributes to disease onset and progression, and UCP2 expression is induced in an effort to dampen ROS generation and to prevent further oxidative damage, and 3) this adaptive change leading to UCP2 expression leads to decreased ATP production, thus hindering various ATP-dependent cellular processes and ultimately contributing to compromised myocardial function and heart failure.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $10,386 )
2008	2008	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07101	ESSEX	USA	Alcohol Research Programs	001	4	6/18/2008	SUPPLEMENT FOR EXPANSION	$10,386
														Subtotal = $10,386

Issue Date FY: 2007 ( Subtotal = $22,123 )
2007	2007	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07101	ESSEX	USA	Alcohol National Research Service Awards for Research Training	000	4	6/21/2007	NON-COMPETING CONTINUATION	$22,123
														Subtotal = $22,123

Issue Date FY: 2006 ( Subtotal = $40,296 )
2006	2006	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07101	ESSEX	USA	Alcohol National Research Service Awards for Research Training	000	3	6/13/2006	NON-COMPETING CONTINUATION	$40,296
														Subtotal = $40,296

Issue Date FY: 2005 ( Subtotal = $29,157 )
2005	2005	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07101	ESSEX	USA	Alcohol National Research Service Awards for Research Training	000	2	6/20/2005	NON-COMPETING CONTINUATION	$29,157
														Subtotal = $29,157

Issue Date FY: 2004 ( Subtotal = $29,157 )
2004	2004	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	65 BERGEN STREET	NEWARK	NJ	07101	ESSEX	USA	Alcohol National Research Service Awards for Research Training	000	1	5/26/2004	NEW	$29,157
														Subtotal = $29,157

Grand Total All Awards = $131,119

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ROLE OF UNCOUPLING PROTEIN-2 IN ALCOHOLIC CARDIOMYOPATHY

Award Number: F30AA015004

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/01/2008

PERIOD OF PERFORMANCE END DATE: 06/30/2008

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