Thursday, August 21, 2025 8/21/2025

Defining the Autonomic Cerebellum in Autism

Award Number: DP5OD036148
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/21/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Defining the Autonomic Cerebellum in Autism - PROJECT SUMMARY/ABSTRACT Autism spectrum disorder (ASD) is a prevalent and disabling neurodevelopmental disorder that takes a significant toll on patients, their families, and the national economy. There are no targeted treatments for the dysregulated autonomic responses, or dysautonomia, that affect and disable over 70% of autistic children. Most current medical approaches are non-selective, ineffective, and associated with side effects. Thus, a novel and targeted therapy is urgently needed for refractory dysautonomia in ASD. Given dysautonomia is thought to arise from a problem in how the brain regulates peripheral autonomic organs, a major barrier to progress has been an incomplete understanding of the neural networks that influence peripheral autonomic output. Recently, I identified the sites of the cerebellum that are major sources of descending control over the adrenal medulla, an autonomic organ that releases adrenaline and initiates the body-wide sympathetic response. Cerebellar involvement is clinically relevant because dysautonomia and cerebellar abnormalities are both present in ASD and the superficial location of the cerebellum makes it an attractive target for non-invasive trans-cranial magnetic stimulation (TMS). Yet, two remaining knowledge gaps prevent clinical translation: we do not know which sites of the ‘autonomic cerebellum’ influence the physiologic responses perturbed in dysautonomia and how these sites are affected in conditions like ASD where dysautonomia and cerebellar abnormalities are present. The goals of this project are to fill these gaps by defining the regions of the autonomic cerebellum that selectively control physiologic responses and by testing how these cerebellar networks are altered in a model of autism. Specifically, Aim 1 is to test if modulating the adrenal-related cerebellum alters autonomic physiologic responses. Aim 2 is to test if autonomic responses are abnormal in a marmoset model of ASD. Aim 3 is to test if the cerebellar sites that control the adrenal’s sympathetic output are altered in a marmoset model of ASD. I will employ in vivo recording of autonomic physiologic responses and trans-neuronal transport of rabies virus to establish the behavioral and systems neuroscience foundations for how the autonomic cerebellum is affected in ASD. These studies have the potential to identify specific cerebellar regions to target with a new treatment approach (e.g., cerebellar TMS) that aims to normalize refractory dysautonomia in ASD. Thus, the results of the proposed work may ultimately transform how we manage dysautonomia in ASD and other disorders associated with cerebellar abnormalities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $390,000 )
2025	2025	NORTHEAST OHIO MEDICAL UNIVERSITY	4209 STATE ROUTE 44	ROOTSTOWN	OH	44272	PORTAGE	USA	Trans-NIH Research Support	000	3	8/4/2025	NON-COMPETING CONTINUATION	$390,000
														Subtotal = $390,000

Issue Date FY: 2024 ( Subtotal = $390,000 )
2024	2024	NORTHEAST OHIO MEDICAL UNIVERSITY	4209 STATE ROUTE 44	ROOTSTOWN	OH	44272	PORTAGE	USA	Trans-NIH Research Support	001	2	8/13/2024	NON-COMPETING CONTINUATION	$390,000
2024	2023	NORTHEAST OHIO MEDICAL UNIVERSITY	4209 STATE ROUTE 44	ROOTSTOWN	OH	44272	PORTAGE	USA	Trans-NIH Research Support	000	1	2/15/2024	NEW	$0
														Subtotal = $390,000

Issue Date FY: 2023 ( Subtotal = $390,000 )
2023	2023	NORTHEAST OHIO MEDICAL UNIVERSITY	4209 STATE ROUTE 44	ROOTSTOWN	OH	44272	PORTAGE	USA	Trans-NIH Research Support	000	1	9/21/2023	NEW	$390,000
														Subtotal = $390,000

Grand Total All Awards = $1,170,000

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Defining the Autonomic Cerebellum in Autism

Award Number: DP5OD036148

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/21/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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