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Implantable Nanophotonic Sensors for in Vivo Immunoresponse

Award Number: DP2DE030713
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Implantable Nanophotonic Sensors for in Vivo Immunoresponse - PROJECT SUMMARY Visualizing real-time physiologic and molecular tumor response to targeted molecular agents and radiation, within the complex in situ host environment - in effect a wireless biopsy - provides a heretofore unseen window into cancer biology, guiding optimal, personalized patient care. We aim to develop a versatile platform imaging the dynamic immune response within the patient’s tumor microenvironment. Here we introduce a first-in-class, fully implantable, wireless, microfabricated electronic-photonic platform for real-time in vivo tumor monitoring. This platform can be utilized with any tumor type as well as non-oncologic applications where biomarkers are essential. The platform will provide the full functionality of a fluorescence microscope, in a millimeter-scale implantable sensor. in vivo microscopy enables intratumoral fluorescent imaging, leveraging an armamentarium of existing targeted biologics unveiling both tumor biology within the complex host environment and early indicators of tumor response. We will detect and explore the role of the immune response at the site of disease dramatically increasing sensitivity while providing spatial localization - key to unlocking a systemic effect. Made possible by recent innovations in wireless power and data transfer, and unprecedented integration of high-speed circuits with photonics, these advances will unlock an entirely new paradigm of real- time response assessment enabling effective application of novel therapeutics and immunotherapy, customized to patient’s tumor biology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$83,883 )
2026	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Oral Diseases and Disorders Research	000	1	10/1/2025	NEW	-$66,570
2026	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Oral Diseases and Disorders Research	001	1	10/1/2025	NEW	-$17,313
														Subtotal = -$83,883

Issue Date FY: 2020 ( Subtotal = $2,422,500 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Oral Diseases and Disorders Research	000	1	9/10/2020	NEW	$2,422,500
														Subtotal = $2,422,500

Grand Total All Awards = $2,338,617

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Implantable Nanophotonic Sensors for in Vivo Immunoresponse

Award Number: DP2DE030713

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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