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Restoring Speech with an Intracortical Neuroprosthesis for Post-Stroke Agrammatic Aphasia

Award Number: DP2DC024816
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/02/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Restoring Speech with an Intracortical Neuroprosthesis for Post-Stroke Agrammatic Aphasia - Project Summary One in four people will have a stroke in their lifetime, and approximately one third of survivors develop aphasia. Stroke survivors consistently identify aphasia as the most debilitating post-stroke deficit, yet effective interventions to restore fluent speech remain limited. This proposal seeks to address this critical gap by developing and validating an intracortical neuroprosthesis to restore naturalistic speech in people living with post- stroke agrammatic aphasia. Building on prior success restoring communication in people with dysarthria due to ALS, I propose to implant intracortical microelectrode arrays in two participants with post-stroke aphasia enrolled into the BrainGate2 clinical trial. Recordings will be obtained from the non-dominant ventral precentral gyrus and superior temporal gyrus, two critical nodes of the speech and language network. Using modern deep- learning frameworks, neural features will be decoded into phonemes and words, enabling real-time communication. The project has two primary goals. The first is to create a restorative neuroprosthesis that enables more fluid and intelligible communication for people with agrammatic aphasia. The second is to develop the system as a rehabilitation device, using time-locked and context-aware auditory cues to help participants regain independent speech through closed-loop learning. Performance will be benchmarked against baseline speech capacity and validated using established measures of intelligibility, fluency, and communicative ease. By addressing a condition that affects millions of stroke survivors, this research has the potential to transform functional communication and substantially improve quality of life. Beyond its clinical impact, the project will provide fundamental insights into how cortical networks generate speech after brain injury.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $529,407 )
2026	2026	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Research Related to Deafness and Communication Disorders	000	1	9/4/2026	NEW	$529,407
														Subtotal = $529,407

Grand Total All Awards = $529,407

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Restoring Speech with an Intracortical Neuroprosthesis for Post-Stroke Agrammatic Aphasia

Award Number: DP2DC024816

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/02/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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