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Regulatory genomics of T cells in mouse and human

Award Number: DP2AI171161
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/19/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Regulatory genomics of T cells in mouse and human - Project Summary/Abstract T cells coordinate systemic immunity and are essential for defense against viral and bacterial infections and tu- mors. The long-term goal of our research program is to employ innovative experimental genomics to build multi- dimensional data resources and develop new computational methods that we will use to obtain a comprehensive understanding at a molecular level of T cell activation and differentiation in response to various stimuli. We will address speciﬁc problems about T cell commitment to functional fates across contexts, regulatory mechanisms of these processes and their underlying transcription factors. Unprecedented resolution and statistical power will allow us to study similarities and differences of these mechanisms between T cell lineages and subpopulations, and generalizability of these observations from mouse to human. This goal will be achieved by executing three projects. We will study regulation of T cell activation and functional commitment in lymphocytic choriomeningi- tis virus (LCMV) infection model with a focus on the progenitor TCF1+ T cells (Project 1), transcriptional and epigenetic regulation and higher order chromatin organization in Treg cells (Project 2). Finally, we will build a database, methods, software and interfaces for comparative analysis of regulatory genomics data across mouse models and humans, allowing many fundamental and translational applications (Project 3). These studies will lead to future research and development of new therapeutic transcription factor and other targets and modulation strategies in diseases of dysregulated T cell immunity. Our data resources and methods will enable systematic data exploration, generation and validation of new speciﬁc hypotheses about molecular mechanisms of T cell function, and will provide a platform for mapping and analyzing new T cell data from new systems that we and others will generate in the future.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $482,900 )
2025	2025	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Allergy and Infectious Diseases Research	000	4	6/23/2025	NON-COMPETING CONTINUATION	$482,900
														Subtotal = $482,900

Issue Date FY: 2024 ( Subtotal = $482,900 )
2024	2024	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Allergy and Infectious Diseases Research	000	3	6/24/2024	NON-COMPETING CONTINUATION	$482,900
														Subtotal = $482,900

Issue Date FY: 2023 ( Subtotal = $476,700 )
2023	2023	THE TRUSTEES OF PRINCETON UNIVERSITY	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Allergy and Infectious Diseases Research	000	2	6/9/2023	NON-COMPETING CONTINUATION	$476,700
														Subtotal = $476,700

Issue Date FY: 2022 ( Subtotal = $476,700 )
2022	2022	TRUSTEES OF PRINCETON UNIVERSITY, THE	1 NASSAU HALL	PRINCETON	NJ	08544	MERCER	USA	Allergy and Infectious Diseases Research	000	1	7/19/2022	NEW	$476,700
														Subtotal = $476,700

Grand Total All Awards = $1,919,200

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Regulatory genomics of T cells in mouse and human

Award Number: DP2AI171161

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/19/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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