Tuesday, August 12, 2025 8/12/2025

Breaking the Barrier to an HIV Vaccine

Award Number: DP1AI175471
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Breaking the Barrier to an HIV Vaccine - PROJECT SUMMARY HIV remains the most consequential zoonosis of the last century, with 36 million fatalities and another 37 million infected. Even today, almost 2,000 people per day die of HIV/AIDS globally. Medications are reducing the effects of HIV on the human body and transmission of the virus to others. However, 40 years into the pandemic, there are no vaccines. Effective HIV vaccines remain our only hope of ending the HIV/AIDS pandemic once and for all. HIV vaccines are mostly developed in macaque monkeys, although this primate model of HIV infection has many limitations. Here, we explore a new animal model for HIV infection that recapitulates all key milestones in HIV acute infection and in the establishment of the latent viral reservoir. We develop the tools necessary to turn this into the long-sought model for HIV vaccine development. This new animal model will provide the perfect system to study the immune correlates of protection, the breadth of cross-protection against different HIV-1 subtypes, and to test and develop vaccine candidates.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,095,500 )
2025	2025	THE REGENTS OF THE UNIVERSITY OF COLORADO	3100 MARINE ST	BOULDER	CO	80309	BOULDER	USA	Trans-NIH Research Support	000	4	8/1/2025	NON-COMPETING CONTINUATION	$1,095,500
														Subtotal = $1,095,500

Issue Date FY: 2024 ( Subtotal = $1,095,500 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	3100 MARINE ST	BOULDER	CO	80309	BOULDER	USA	Trans-NIH Research Support	000	3	7/24/2024	NON-COMPETING CONTINUATION	$1,095,500
														Subtotal = $1,095,500

Issue Date FY: 2023 ( Subtotal = $1,095,500 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Trans-NIH Research Support	000	2	7/27/2023	NON-COMPETING CONTINUATION	$1,095,500
														Subtotal = $1,095,500

Issue Date FY: 2022 ( Subtotal = $1,095,500 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	Trans-NIH Research Support	000	1	9/22/2022	NEW	$1,095,500
														Subtotal = $1,095,500

Grand Total All Awards = $4,382,000

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Breaking the Barrier to an HIV Vaccine

Award Number: DP1AI175471

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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