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Host-Directed Strategies to Create Synergistic Antibacterial Therapies

Award Number: DP1AI124619
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2015
PERIOD OF PERFORMANCE END DATE: 07/31/2021

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Host-Directed Strategies to Create Synergistic Antibacterial Therapies - DESCRIPTION (provided by applicant): Emerging antibiotic resistance is a global health crisis. From broadly resistant "superbugs" to extremely drug resistant Mycobacterium tuberculosis (XDR-TB), the specter of untreatable bacterial infection has become an alarming reality. The problem has become so acute that President Barack Obama recently issued an executive order calling multidrug resistant bacteria a national security priority. Likewise, the need to develop better antibiotics that shorten the treatment time to cure persistent bacterial infections also remains a major goal, especially for some of the most notorious pathogens of man, including M. tuberculosis. Due to the slow rate of new antibiotics emerging from the lab, countering antibiotic resistance and persistence by modifying existing drugs or developing inhibitors to new bacterial targets is unlikely to keep up with the increasing demand. The goal of this project is to take a radically different approach to new antibiotic development by identifying small molecules that target powerful host immune pathways of innate immune cells, creating adjunctive therapies that will synergize with conventional antibiotics. This approach is antithetical to traditional antibiotic development programs, which seek to identify molecular inhibitors that target essential pathways of the bacterium but avoid host pathways. The potential impact of "Host-Directed Therapies" (HDTs) could be dramatic, as they may re-sensitize drug-resistant strains and shorten the time to eradicate chronic infections. In particular, this proposa seeks to translate our understanding of host-pathogen interactions into a novel program for identifying small molecules targeting host processes that will synergize with traditional antibiotics during TB infection. The implications of success may extend beyond bacterial infection, as this approach could have huge implications for a broad range of infectious agents, and even boost vaccine efficacy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $28 )
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Trans-NIH Research Support	000	6	10/21/2022	NON-COMPETING CONTINUATION	$28
														Subtotal = $28

Issue Date FY: 2022 ( Subtotal = -$55 )
2022	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Trans-NIH Research Support	000	6	4/5/2022	NON-COMPETING CONTINUATION	-$55
														Subtotal = -$55

Issue Date FY: 2019 ( Subtotal = $785,000 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Trans-NIH Research Support	000	6	8/5/2019	NON-COMPETING CONTINUATION	$785,000
														Subtotal = $785,000

Issue Date FY: 2018 ( Subtotal = $785,000 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Trans-NIH Research Support	000	5	7/27/2018	NON-COMPETING CONTINUATION	$785,000
														Subtotal = $785,000

Issue Date FY: 2017 ( Subtotal = $785,000 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Trans-NIH Research Support	000	4	7/21/2017	NON-COMPETING CONTINUATION	$785,000
														Subtotal = $785,000

Issue Date FY: 2016 ( Subtotal = $761,827 )
2016	2016	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Trans-NIH Research Support	002	3	7/20/2016	NON-COMPETING CONTINUATION	$785,000
2016	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Trans-NIH Research Support	000	1	3/9/2016	NEW	-$716,094
2016	2015	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Trans-NIH Research Support	001	2	3/9/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$692,921
														Subtotal = $761,827

Issue Date FY: 2015 ( Subtotal = $792,500 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Trans-NIH Research Support	000	1	9/11/2015	NEW	$792,500
														Subtotal = $792,500

Grand Total All Awards = $3,909,300

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Host-Directed Strategies to Create Synergistic Antibacterial Therapies

Award Number: DP1AI124619

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2015

PERIOD OF PERFORMANCE END DATE: 07/31/2021

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