Wednesday, October 1, 2025 10/1/2025

Peripheral nervous system aging

Award Number: DP1AG100833
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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Peripheral nervous system aging - Summary Aging alters the function of every organ. An inherent limitation to our understanding of aging is the complexity of the aging process. Thus, fundamental questions remain entirely unanswered: Are there mechanisms that coordinate organ function and how do they deteriorate with age? Could such mechanisms be restored to promote longevity? Previous work has revealed how immune cells and blood factors can impact organ aging and orchestrate organ communication. However, it remains entirely mysterious whether other synchronization systems could regulate organ aging. We are interested in the peripheral nervous system, which connects the brain to all organs, and whether it could coordinate the tempo of aging. This is a challenging problem because aging is a complex process and organ innervation by the peripheral nervous system is extraordinarily diverse. Our lab has recently generated paradigm-shifting methods to study complex aging biology. We have developed machine learning approaches coupled to spatial transcriptomics to determine the age of multiple cell types and to understand the impact cells have on neighboring cells within an organ. In addition, we have recently developed the first in vivo screens for brain aging in mice. Finally, we have established a new vertebrate model system, the African killifish, to perform aging studies at scale. The time is right to leverage these cutting-edge tools and develop new ones to understand how organ innervation responds to aging and to identify targeted approaches to boost the peripheral nervous system to “re-set” organ function and coordination during aging. We are interested in the following high-risk, high-reward questions: What are the age- dependent changes in the peripheral nervous system and how do they differ in diverse organs? How is the activity of peripheral neurons influenced by environmental stimuli that impact longevity? Is the peripheral nervous system functionally implicated in organ aging and how does it coordinate organ aging? Could the tempo of organ aging be “re-set” by restoring organ innervation? Addressing these questions has the potential to revolutionize how we think about aging and could lead to entirely new strategies to counter aging and diseases. More generally, solutions to this challenge could be broadly applied to other biological phenomena where time and organ coordination are critical.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,078,000 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Aging Research	000	1	9/15/2025	NEW	$1,078,000
														Subtotal = $1,078,000

Grand Total All Awards = $1,078,000

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Peripheral nervous system aging

Award Number: DP1AG100833

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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