TMWIHC Overdose and Poisoning Prevention Education Initiative - The Tuolumne Me-Wuk Indian Health Center (TMWIHC) proposes the Overdose and Poisoning Prevention Education Initiative to reduce the risk of unintentional poisoning and overdose within the Tuolumne Me-Wuk tribal community. Over the past several decades, the Tribe has worked to strengthen community wellness by building programs that address health disparities and create culturally relevant prevention opportunities. This project focuses on education as the key strategy to increase knowledge and adoption of safe medication practices. Through this initiative, TMWIHC will conduct culturally tailored community education events, workshops, and talking circles; train Community Champions to serve as peer educators; and implement awareness campaigns using printed and visual materials. These activities aim to reach 80% of tribal households over the project period and build long-term community capacity for overdose prevention. Expected outcomes include increased knowledge and awareness of safe medication practices, widespread adoption of preventive behaviors, strengthened peer support networks, and sustained community engagement. Longer-term goals are reduced unintentional poisoning and overdose incidents and improved community resilience. The project will be managed by TMWIHC’s Tribal Health Outreach Department, leveraging experienced personnel, community partnerships, and organizational infrastructure to ensure effective implementation and sustainability.