Delta THRIVE (Transforming Health Response, Information & Vaccine Equity) will develop, implement and evaluate a culturally appropriate COVID health literacy intervention and sustained adherence strategy that complies with National CLAS Standards and promotes several Healthy People 2030 objectives. Washington County, Mississippi (lead applicant) will partner with Aaron E. Henry Community Health Center (federally qualified health center) and the Mississippi State Department of Health to engage over 20 grassroots collaborators to develop a tailored health literacy intervention reaching extremely rural communities across a 6,000 square mile rural area as defined by HRSA. The focus population includes over 200,000 residents living in 11 fully rural counties of Northwest Mississippi in the Delta region: Bolivar, Coahoma, Humphreys, Issaquena, Leflore, Sharkey, Sunflower, Quitman, Tate, Tunica, and Washington. In these counties, two-thirds of residents (66.9%) identify as Black, 30.9% white and 1.9% Hispanic. Fewer than 20% of focus area residents are fully vaccinated for COVID-19. Mississippi Valley State University, a Minority Serving Institution located in the service region, will advise the project?s disparities impact statement, quality improvement infrastructure and program evaluation.