Community Project Funding/Congressionally Directed Spending - Construction - This project includes three construction projects: the Roy Blunt NextGen Precision Health Building initial construction (NGPH Construction); the Roy Blunt NextGen Precision Health Building Level 4 Shell Space Fitout (NGPH Fitout); and the NextGen University of Missouri Research Reactor West building addition (NextGen MURR West). NGPH Construction, NGPH Fitout, and NextGen MURR West provide the facilities and resources needed to integrate multidisciplinary laboratory space with advanced analytical instrumentation, computational processing, and pilot-scale manufacturing to create a comprehensive precision health research pipeline that encompasses the entire university system. Prior, initial construction expenses for the NGPH construction and construction NGPH fitout include exterior construction, interior construction of office and lab spaces, and equipment purchases. The NextGen MURR West addition involves both exterior and interior construction and equipment purchase to expand the operations at MURR and improve its service to society. Aggressive and deadly disease like cancer, heart disease, and kidney disease have impacted all areas of the United States. Unfortunately, Missouri has been disproportionally affected. According to the 2019 CDC statistics, Missouri is ranked 4thhighest for most kidney disease deaths and 12th highest for cancer deaths, nationally. However, the University of Missouri (MU) has also been at the forefront with research and treatments at a local to global level. This project will further these advancements. This project supports the University of Missouri’s NextGen Precision Health goal to unite talented investigators from across the UM System: University of Missouri – Columbia (MU), University of Missouri – Kansas City (UMKC), Missouri University of Science and Technology (Missouri S&T), and University of Missouri – St. Louis (UMSL) with a cutting-edge research facility dedicated to solving our most pressing health concerns. Designed to empower interdisciplinary collaboration as the cornerstone of the initiative, the building will provide the collaborative nexus for activity focused on speeding the path to new treatments and making them accessible to people in need, faster than traditional bench-to-bedside methods. As one of only six public universities in the country with schools or colleges of medicine, veterinary medicine, agriculture, engineering, arts and science, law, and a powerful research reactor — all on one campus — MU is uniquely positioned to meet the challenges of precision health. Our position is further strengthened by MU Health, our academic health system that is home to groundbreaking research, and has headquarters located right next to the NextGen building. Additionally, for more than 50 years the faculty and staff of the University of Missouri Research Reactor (MURR®) have promoted groundbreaking research and developed life-saving radiopharmaceuticals, providing benefits to people across the country and around the world. MURR is the highest-power university research reactor in the United States, operating at 10 megawatts, 6.5 days a week and 52 weeks a year. The MURR facility enables research across many disciplines such as analyzing industrial materials and developing radiopharmaceuticals that have lifesaving clinical applications. Research through the University of Missouri’s NextGen Precision Health will provide major returns on investment through healthier communities, better educational opportunities for students, game-changing economic development, and new precision health technologies for Missouri and beyond. Combining our collective expertise and world-class resources will allow MU researchers to effectively analyze and develop solutions to our critical health challenges and deliver treatments with access for all, improving the lives of people living in urban, rural and remote communities from the local, state, country, and global levels.