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Further expansion of the Southwest National Primate Research Center Specific Pathogen Free Rhesus Macaque Resource

Award Number: C06OD036038
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: CONSTRUCTION
PERIOD OF PERFORMANCE START DATE: 09/08/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Further expansion of the Southwest National Primate Research Center Specific Pathogen Free Rhesus Macaque Resource - Abstract The Southwest National Primate Research Center (SNPRC) houses a Specific Pathogen Free (SPF) rhesus macaque colony of Indian origin (Ind RM), supported by the NIH SPF rhesus breeding program (U42OD010442), and a smaller SPF P51 supported colony. We currently house ~1000 rhesus macaques, of which the U42 colony of approximately 800 animals supports AIDS-related research both at SNPRC and through sales to AIDS investigators at other institutions. However, there is a major national shortage of research nonhuman primates (NHPs), and particularly of SPF Ind RM. This has severely impacted our ability to support the national and international research mission of HIV/AIDS as well as in the area of non-AIDS/other infectious diseases, AIDS co-infections, malaria, TB, COVID-19, etc. The NIH has recognized this need for expansion of SPF rhesus production and strongly recommends increasing Ind RM breeding capacity. The SNPRC is well positioned to expand its SPF Ind RM production as a center located in a climate hospitable to largely outdoor housing, at an institution with capacity for expansion. Our host institution, Texas Biomed, raised funds and is currently building new NHP facilities which will house ~600 NHPs. Texas Biomed/SNPRC has also been funded by the NIH/ORIP to expand our production capacity by 30% over our existing capacity via other mechanisms. Finally, through Texas Biomed support, we have procured ~150 conventional founder/breeder Ind RM. This founder colony has increased the number of breeding pairs the SNPRC macaque colony management team can generate, and it is expected that in the upcoming birthing season, ~200 RM live births will occur, double that of each of the last several years. As such the SNPRC Ind RM population can increase to 1500+ in the next five years. Funded partially by this C06, we seek to construct an additional animal housing/breeding facility adjacent the two new holding/breeding facilities currently under construction, as part of the overall $45M long term Animal Care Complex project. This will further allow us to house, breed and maintain an additional supply of ~300 Ind RM for AIDS/emerging infectious diseases research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2023	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Construction Support	000	1	1/22/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Construction Support	000	1	2/26/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Construction Support	000	1	4/11/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $8,000,000 )
2023	2023	TEXAS BIOMEDICAL RESEARCH INSTITUTE	8715 W MILITARY DR	SAN ANTONIO	TX	78227	BEXAR	USA	Construction Support	000	1	9/8/2023	NEW	$8,000,000
														Subtotal = $8,000,000

Grand Total All Awards = $8,000,000

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Further expansion of the Southwest National Primate Research Center Specific Pathogen Free Rhesus Macaque Resource

Award Number: C06OD036038

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: CONSTRUCTION

PERIOD OF PERFORMANCE START DATE: 09/08/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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