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CUREIT: Curing the Uncurable via RNA-Encoded Immunogene Tuning

Award Number: AY1AX000001
ORGANIZATION: ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 08/23/2023
PERIOD OF PERFORMANCE END DATE: 08/22/2026

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CUREIT: Curing the Uncurable via RNA-Encoded Immunogene Tuning - More than 25 million Americans currently live with autoimmune disease, and almost two million are projected to be diagnosed with cancer in 2023. Immune dysregulation is an underlying component of not only cancer and autoimmune diseases, but also infectious diseases, transplant rejection, and other common medical conditions. Current methods of immune modulation used to treat and mitigate these conditions are often expensive or not completely effective. Curing the Uncurable via RNA-Encoded Immunogene Tuning (CUREIT) aims to address immune dysregulation by directly programming immune cell function. Advances in gene-encoded technology will be leveraged to develop a platform capability able to both enhance protective immune responses as well as modulate insufficient or ineffective immune profiles. CUREIT seeks to develop a disease-agnostic toolbox of methods and technologies, including the in vivo delivery of mRNA-based drugs, cell targeting lipid nanoparticles, and ex vivo modulation of immune cells. This technology has the potential to make significant advancements towards managing or eliminating many diseases and conditions affecting all ages and demographics, including diseases which are currently untreatable.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	EMORY UNIVERSITY	201 DOWMAN DR NE	ATLANTA	GA	30322	DEKALB	USA	ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H)	000	1	4/23/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H)	000	1	2/29/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $24,754,589 )
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H)	001	1	9/29/2023	NEW	$0
2023	2023	EMORY UNIVERSITY	201 DOWMAN DR	ATLANTA	GA	30322	DEKALB	USA	ADVANCED RESEARCH PROJECTS AGENCY for HEALTH (ARPA-H)	000	1	8/23/2023	NEW	$24,754,589
														Subtotal = $24,754,589

Grand Total All Awards = $24,754,589

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CUREIT: Curing the Uncurable via RNA-Encoded Immunogene Tuning

Award Number: AY1AX000001

ORGANIZATION: ADVANCED RESEARCH PROJECTS AGENCY FOR HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 08/23/2023

PERIOD OF PERFORMANCE END DATE: 08/22/2026

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