Endometriosis is estimated to impact one in ten women of reproductive age within the United States, and painful and debilitating symptoms often begin during adolescence. Despite lengthy diagnostic delays, little public health intervention has aimed towards increasing disease literacy among adolescents and clinicians who serve them. Beyond disease literacy, societal stigma against discussing menstrual health and minimization of pelvic pain further inhibit disease recognition and awareness. Undiagnosed endometriosis and toxic stress due to stigma can harm adolescents later in life, including maternal health. Through a partnership between George Mason University, INOVA Health, and Gaming Revolution for International Development, we will implement a multi-component demonstration project that involves a) universal screening of adolescent patients in clinics, b) a serious gaming intervention designed to increase awareness, self-tracking of symptoms, and self-efficacy and coping, and c) follow-up appointments with clinicians following game play. Using a type 1 hybrid effectiveness trial, we will assess acceptability, feasibility and sustainability as well as impacts on endometriosis awareness, coping, self-efficacy, perceived support, and trust in health care workers.