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A Multi-Center Clinical Trial to Evaluate the Effectiveness of Intermittent Hypoxia Therapy in Individuals with Spinal Cord Injury

Award Number: 90SIMS0001
ORGANIZATION: NATIONAL INSTITUTE ON DISABILITY, INDEPENDENT LIVING, AND REHABILITATION RESEARCH
OPDIV: ACL
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 09/30/2017
PERIOD OF PERFORMANCE END DATE: 09/29/2025

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A Multi-Center Clinical Trial to Evaluate the Effectiveness of Intermittent Hypoxia Therapy in Individuals with Spinal Cord Injury - The Shirley Ryan AbilityLab, in collaboration with the University of Miami and Kessler Institute for Rehabilitation, seek to evaluate a promising new treatment strategy for persons with spinal cord injury (SCI), using brief reductions in oxygen levels in the inspired air. Our trial brings together an accomplished team of scientists and clinicians, with input from caregivers and persons with SCI, from three leading SCI rehabilitation institutions. While treatment options for persons with SCI have greatly improved, they are still limited in efficacy. The goal of this proposal is to evaluate a new strategy called acute intermittent hypoxia (AIH), during which a person is administered brief bouts of low oxygen through a facemask. AIH triggers the synthesis and release of specific spinal proteins that promote effective increased neural plasticity, improving muscle contractions. Our objective is to test whether daily AIH improves upper-limb function in persons with incomplete cervical SCI. We will evaluate training when AIH is used alone, in combination with task-specific traditional training, or using a sensorized robotic device (RAPAEL Smart Glove). We hypothesize that combining training protocols with AIH will bolster the effectiveness of current therapies above that resulting from conventional therapies alone. As such, this proposal specifically relates to NIDILRR’s health and function domain. Outcomes will show improvement in hand and arm function, enhanced reintegration into social and vocational activities, and a greater understanding of hypoxia-induced neuroplasticity. Products include establishing new design criteria for hypoxia devices, comprehensive data on the impact of AIH on the upper limb function, as well as journal publications, and training materials for patients, caregivers, and clinicians.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	REHABILITATION INSTITUTE OF CHICAGO	355 E ERIE ST	CHICAGO	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	03	5	10/1/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
2025	2020	REHABILITATION INSTITUTE OF CHICAGO	355 E ERIE ST	CHICAGO	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	03	5	10/1/2024	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	REHABILITATION INSTITUTE OF CHICAGO	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	5	10/20/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2021	REHABILITATION INSTITUTE OF CHICAGO	355 E ERIE ST	CHICAGO	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	02	5	9/26/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2020	REHABILITATION INSTITUTE OF CHICAGO	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	5	10/20/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2023	2020	REHABILITATION INSTITUTE OF CHICAGO	355 E ERIE ST	CHICAGO	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	02	5	9/26/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2018	REHABILITATION INSTITUTE OF CHICAGO	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	04	3	9/29/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2018	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	03	3	6/29/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2017	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	03	3	6/29/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $899,725 )
2021	2021	REHABILITATION INSTITUTE OF CHICAGO	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	5	7/16/2021	NON-COMPETING CONTINUATION	$899,725
2021	2020	REHABILITATION INSTITUTE OF CHICAGO	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	5	7/16/2021	NON-COMPETING CONTINUATION	$0
2021	2020	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	4	2/9/2021	OTHER REVISION	$0
2021	2019	REHABILITATION INSTITUTE OF CHICAGO	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	5	7/16/2021	NON-COMPETING CONTINUATION	$0
2021	2019	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	4	2/9/2021	OTHER REVISION	$0
2021	2018	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	4	2/9/2021	OTHER REVISION	$0
2021	2018	REHABILITATION INSTITUTE OF CHICAGO	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	5	7/16/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $899,725

Issue Date FY: 2020 ( Subtotal = $899,940 )
2020	2020	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	4	7/28/2020	NON-COMPETING CONTINUATION	$899,940
2020	2019	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	02	3	1/23/2020	OTHER REVISION	$0
2020	2019	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	3	10/18/2019	OTHER REVISION	$0
2020	2018	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	02	3	1/23/2020	OTHER REVISION	$0
														Subtotal = $899,940

Issue Date FY: 2019 ( Subtotal = $899,984 )
2019	2019	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	3	8/14/2019	NON-COMPETING CONTINUATION	$899,984
2019	2017	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	2	3/26/2019	OTHER REVISION	$0
														Subtotal = $899,984

Issue Date FY: 2018 ( Subtotal = $899,824 )
2018	2018	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	2	8/8/2018	NON-COMPETING CONTINUATION	$899,824
2018	2017	Rehabilitation Institute Of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	1	12/18/2017	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $899,824

Issue Date FY: 2017 ( Subtotal = $899,985 )
2017	2017	Rehabilitation Institute of Chicago	355 East Erie	Chicago	IL	60611	COOK	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	1	9/25/2017	NEW	$899,985
														Subtotal = $899,985

Grand Total All Awards = $4,499,458

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A Multi-Center Clinical Trial to Evaluate the Effectiveness of Intermittent Hypoxia Therapy in Individuals with Spinal Cord Injury

Award Number: 90SIMS0001

ORGANIZATION: NATIONAL INSTITUTE ON DISABILITY, INDEPENDENT LIVING, AND REHABILITATION RESEARCH

OPDIV: ACL

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 09/30/2017

PERIOD OF PERFORMANCE END DATE: 09/29/2025

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