Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

INFLUENCE OF SOCKET ADDUCTION ON JOINT LOADING FOR INDIVIDUALS WITH TRANSFEMORAL AMPUTATION

Award Number: 90SFGE0067
ORGANIZATION: NATIONAL INSTITUTE ON DISABILITY, INDEPENDENT LIVING, AND REHABILITATION RESEARCH
OPDIV: ACL
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER
PERIOD OF PERFORMANCE START DATE: 09/30/2024
PERIOD OF PERFORMANCE END DATE: 09/29/2027

Group Awards By:

View Award Description

INFLUENCE OF SOCKET ADDUCTION ON JOINT LOADING FOR INDIVIDUALS WITH TRANSFEMORAL AMPUTATION - By the year 2050, the number of individuals living with major lower-limb amputations in the U.S. is projected to surpass 3.5 million. These individuals often face challenges like knee osteoarthritis (OA) and hip pain due to changes in their mobility and walking patterns. Those with transfemoral amputation (TFA), where the amputation is above the knee, are particularly at a higher risk for these detrimental issues. After TFA, proper alignment of the amputated thigh bone within the socket is essential for comfort and proper function when performing activities of daily living using a prosthesis. Misalignment of the prosthesis can lead to walking problems and muscle issues. Research shows that aligning the limb in a way that keeps the amputated thigh bone in adduction (i.e., towards the body's midline) can improve stability but has mixed effects on mechanical factors in walking. Recent studies suggest that this alignment increases certain forces on the lower limbs. However, these forces are a rough estimate and cannot accurately measure the internal stresses on the lower-limb joints. Due to the difficulty of measuring joint forces experimentally without instrumented surgical interventions, musculoskeletal (MSK) modeling and simulation is a promising approach to better estimate joint forces. Providing a more accurate estimate of forces on the hip and knee joints is warranted to provide insight into lower-limb joint health in individuals with TFA who are at an elevated risk of OA. To better understand how certain forces on the lower limb joints are influenced by prosthetic socket alignment, we propose to perform a within-subject experiment and MSK modeling and simulation with two specific aims. Primary Aim: To examine how different socket alignments affect joint forces in both hips and non-amputated knee of individuals with TFA. We predict that more socket adduction will lead to higher joint forces, with differences depending on the activity. We propose to recruit individuals with unilateral TFA (n=8) to participate in a human subject experiment. Given that different activities affect joint forces, the experiment will involve a set of key daily activities such as walking uphill and downhill, turning, and transitioning from sitting to walking. The experimental data will be used to perform MSK modeling and simulation to estimate joint forces, accounting for forces of muscles crossing the joints, thus providing a more accurate estimation. Secondary Aim: To investigate how socket alignment affects the external adduction moment (EAM) of the hips, which influences the compressive forces leading to hip OA. We hypothesize that greater socket adduction will lower the EAM, with variations across different activities. The experimental data will be analyzed to calculate the EAM of both hips. The expected result of this research is to provide biomechanical evidence of the effects of socket adduction on joint loading, whose changes have been associated with OA, to guide prosthetic alignment in clinical rehabilitation practice. The primary goal is to mitigate the elevated risk of OA, especially in the intact limb, thus enhancing the functional mobility of individuals with TFA. The research aligns with the NIDILRR's mission to improve health, function, and participatory living for individuals with disabilities and fits within their research agenda in prosthetics and orthotics. The long-term goal is to optimize prosthesis function, helping individuals with TFA regain independence and improve their quality of life.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	REDACTED DUE TO PII			WA	98105		USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	02	1	8/14/2026	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	REDACTED DUE TO PII			WA	98105		USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	1	8/20/2025	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $45,000 )
2024	2024	REDACTED DUE TO PII				98105		USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	1	9/16/2024	NEW	$45,000
														Subtotal = $45,000

Grand Total All Awards = $45,000

Top

All Categories

About

Search

Reports

Data Submission

Award Information

INFLUENCE OF SOCKET ADDUCTION ON JOINT LOADING FOR INDIVIDUALS WITH TRANSFEMORAL AMPUTATION

Award Number: 90SFGE0067

ORGANIZATION: NATIONAL INSTITUTE ON DISABILITY, INDEPENDENT LIVING, AND REHABILITATION RESEARCH

OPDIV: ACL

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

PERIOD OF PERFORMANCE START DATE: 09/30/2024

PERIOD OF PERFORMANCE END DATE: 09/29/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer