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The Effectiveness and Underlying Mechanism of a Mindful Attention Program for Traumatic Brain Injury:A Randomized Clinical Trial

Award Number: 90IFRE0016
ORGANIZATION: NATIONAL INSTITUTE ON DISABILITY, INDEPENDENT LIVING, AND REHABILITATION RESEARCH
OPDIV: ACL
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: OTHER

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The Effectiveness and Underlying Mechanism of a Mindful Attention Program for Traumatic Brain Injury:A Randomized Clinical Trial - A significant number of traumatic brain injury (TBI) patients suffer from long lasting cognitive and neurobehavioral symptoms that can affect interpersonal and occupational function. Symptoms includes cognitive deficit such as attention and memory, depression, anxiety and emotional dysregulation. A mindfulness-based training can provide an ideal intervention to address those symptoms and the special needs of the TBI population. Mindfulness training is a process of developing a non-reactive focused attention to all present moment experiences. This process helps develop an expanded self-awareness and a nonjudgmental philosophy for approaching one’s thoughts, emotions, and sensations. MAP is particularly well suited to TBI as it focuses both on developing awareness and attention, which are interrelated and often impaired, and are critical to improve emotional regulation and social functioning, as well as problem solving. To this end, we have developed a modified Mindfulness Based Stress Reduction (MBSR) group intervention called Mindful Attention Program (MAP). Our previous pilot investigations have found encouraging results in both cognitive measures but also clinically meaningful improvements in everyday life function. The current proposal is aimed at further validating the effectiveness and underlying mechanism of MAP to a more severe TBI population using a more rigorous randomized control trials. To this end, 60 moderate to severe post-acute TBI patients with impaired attention will either receive the 10-week MAP intervention or a 10-week psychoeducational and well-being program as an active control intervention. Outcomes will be assessed pre and post intervention, as well as well at 6 months follow-up. We will assess whether MAP shows greater improvement in neurocognitive measures of attention as well as behavioral measures directly related to attention, including metacognition and social monitoring, while exploring its impact on everyday function and quality of life. Using neuroimaging we will also investigate the neural mechanisms of improvement by measuring both functional and structural connectivity associated with attentional regulation. This study will provide new insights not only on the efficacy of MAP in improving task related attentional performance and present moment awareness in TBI, but also on its underlying mechanisms of action. Results from this endeavor will provide valuable information that will ultimately guide the development of an effective intervention that can have a real impact on patients’ ability to resume a fully functional and satisfying life.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	07	3	9/16/2024	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2024	2019	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	07	3	9/16/2024	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	06	3	9/7/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	KESSLER FOUNDATION, INC.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	05	3	9/6/2022	EXTENSION WITH OR WITHOUT FUNDS	$0
2022	2020	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	03	3	10/29/2021	OTHER REVISION	$0
2022	2020	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	02	3	10/15/2021	OTHER REVISION	$0
2022	2019	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	02	3	10/15/2021	OTHER REVISION	$0
2022	2019	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	03	3	10/29/2021	OTHER REVISION	$0
2022	2018	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	02	3	10/15/2021	OTHER REVISION	$0
2022	2018	Kessler Foundation, Inc.	120 Eagle Rock Avenue	East Hanover	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	04	3	6/22/2022	ADMINISTRATIVE SUPPLEMENT ( + OR - ) (DISCRETIONARY OR BLOCK AWARDS)	$0
2022	2018	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	03	3	10/29/2021	OTHER REVISION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	3	9/1/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
2021	2019	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	3	9/1/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
2021	2018	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	01	3	9/1/2021	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $199,931 )
2020	2020	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	3	7/1/2020	NON-COMPETING CONTINUATION	$199,931
														Subtotal = $199,931

Issue Date FY: 2019 ( Subtotal = $199,978 )
2019	2019	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	2	9/10/2019	NON-COMPETING CONTINUATION	$199,978
														Subtotal = $199,978

Issue Date FY: 2018 ( Subtotal = $199,969 )
2018	2018	Kessler Foundation, Inc.	120 Eagle Rock Ave Ste 100	EAST HANOVER	NJ	07936	MORRIS	USA	ACL National Institute on Disability, Independent Living, and Rehabilitation Research	00	1	8/23/2018	NEW	$199,969
														Subtotal = $199,969

Grand Total All Awards = $599,878

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The Effectiveness and Underlying Mechanism of a Mindful Attention Program for Traumatic Brain Injury:A Randomized Clinical Trial

Award Number: 90IFRE0016

ORGANIZATION: NATIONAL INSTITUTE ON DISABILITY, INDEPENDENT LIVING, AND REHABILITATION RESEARCH

OPDIV: ACL

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: OTHER

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