The goal of the University of Washington Traumatic Brain Injury Model System is to improve the lives of individuals with Traumatic Brain Injury (TBI). This has been our mission since 1998 when we were initially funded. The objectives of the current grant are to (1) provide a multidisciplinary system of rehabilitation within a full continuum of medical care, (2) contribute at least 35 subjects per year to the TBIMS national database with excellent follow up of our 1314 currently enrolled subjects, (3) conduct a site-specific study to improve our understanding of the development of chronic pain and use of opioids after TBI, (4) participate in module studies, including the use of exercise as a treatment for Major Depressive Disorder after TBI, and (5) deliver evidence-based, patient-centered information through our website, newsletter, and partnership with the Model System Knowledge Translation Center (MSKTC). Our overall approach is to continue our excellent rates of enrollment and follow up of individuals with TBI and work within our region and across the country to conduct high quality research. Outcomes include (1) meeting or exceeding benchmarks for enrollment and follow up on all studies, (2) successful implementation and collaboration on module projects, (3) improving consumer awareness and education on TBI related topics, including partnering with the Brain Injury Alliance of Washington and MSKTC, and (4) disseminating research findings to other professional and consumer audiences. Products will include successful completion of site-specific and module projects including peer-reviewed publications, consumer friendly educational materials, and presentations at professional and consumer-focused conferences. Duration will be 5 years.