This project conducts new research, disseminates new knowledge to clinicians, researchers, and persons affected by traumatic brain injury (TBI), and provides state-of-the-art clinical care to persons with TBI in greater Philadelphia and Southern New Jersey. The goal of this project is to create and disseminate new knowledge to improve health, function, and quality of life for people with TBI. Objectives are to: (1) study the effects of an innovative remotely delivered program to promote physical activity and reduce sedentary behavior in persons living with chronic TBI; (2) develop and validate a measure of functional outcome after moderate to severe TBI with adequate precision to detect meaningful functional change in clinical research studies; (3) continue significant contributions to the TBI Model System National Database by recruiting 175 new participants and following the 1,350 enrolled in previous years; (4) conduct education and training to enhance knowledge of people with brain injury, their families, and professionals. Project outputs include a regional conference for people with TBI and their families; protocols, guidelines, and treatment materials for promoting physical activity, maximizing learning in inpatient rehabilitation, and remote delivery of cognitive rehabilitation via telehealth; as well as educational materials including professional publications and presentations reporting research results.