To achieve the goal of the Model Systems Knowledge Translation Center (MSKTC) of enhancing the use of research-based information to inform decision making by spinal cord injury (SCI), traumatic brain injury (TBI), and burn injury (Burn) stakeholders, the American Institutes of Research (AIR) will apply the Knowledge to Action (KTA) Framework with an Integrated Knowledge Translation (iKT) approach to its work to address the priorities of the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) during the 2021–26 cycle. Throughout the entire knowledge translation (KT) process, AIR will collaborate with NIDILRR and partners to actively engage members of all four core MSKTC stakeholder groups (people with disabilities and their families; practitioners and clinicians; policymakers and advocates; and Model System and non-Model System researchers) to co-design, co-develop, and co implement all center activities. The objectives of these activities are to conduct research on effective KT methods to increase awareness and use of Model System research; develop research-based, user-friendly products grounded in KT science; conduct KT training and technical assistance activities to increase KT capacities of Model System grantees; disseminate MSKTC resources to all potential stakeholders; and implement utilization activities to promote stakeholders’ use of Model System research and MSKTC resources for informed decision making. The primary outcome of MSKTC is to improve the lives of and services for people with SCI, TBI, and Burn. MSKTC will produce research-based information resources for all stakeholders and make them available on the MSKTC website.