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| Issue Date FY: 2024 ( Subtotal = $98,066,917 ) (Continued on the next page) |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL161507 | A Novel computational approach to optimize Fontan and improve surgical predictability | 000 | 3 | NIH | 2/1/2024 | $538,358 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EY033025 | ECM Regulation of Ocular Surface Disease | 000 | 3 | NIH | 3/13/2024 | $442,500 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DK132348 | Protein Optimization with Exercise to Improve Muscle Mass and Functional Outcomes (PROXIMUS) | 000 | 3 | NIH | 1/16/2024 | $310,173 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL155632 | Transcription Factor 4 Maintain Endothelial identity to Oppose Heart Failure | 000 | 3 | NIH | 11/7/2023 | $451,532 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AR080740 | Skeletal and non-skeletal roles for osteocalcin | 000 | 3 | NIH | 4/2/2024 | $350,460 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99HL169927 | Deciphering the intrinsic myocardial and/or endocardial defects of hypoplastic left heart syndrome | 000 | 1 | NIH | 2/29/2024 | $127,278 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01CA287076 | Activating gasdermin pores to induce pyroptosis and stimulate anti-tumor immunity | 000 | 1 | NIH | 4/4/2024 | $733,069 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HD112379 | Metabolic control of the neural crest epigenome | 000 | 1 | NIH | 2/28/2024 | $560,550 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DE033701 | Architecture and function of the neural crest genome | 000 | 1 | NIH | 3/27/2024 | $554,035 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167925 | Simple and Effective Laceration of Potentially-calcified Leaflets as an Adjunct to Transcatheter Valve Replacement | 000 | 1 | NIH | 1/18/2024 | $808,798 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K01HL171354 | Associations between Perfluoroalkyl Substances (PFAS) Exposure and Aeroallergen Sensitization among Infants at High-Risk for Developing Asthma | 000 | 1 | NIH | 12/15/2023 | $161,316 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99HL171947 | Novel role of Foxc2 in regulating metabolic disease | 000 | 1 | NIH | 11/20/2023 | $125,658 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32HL172637 | Endothelial and mural cell interaction in capillary malformation | 001 | 1 | NIH | 11/20/2023 | $0 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32HL172637 | Endothelial and mural cell interaction in capillary malformation | 000 | 1 | NIH | 11/20/2023 | $71,792 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01EY035684 | Kinase regulators of retinal ganglion cell survival and axon regeneration | 000 | 1 | NIH | 11/21/2023 | $652,092 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U24NS137481 | Brain Malformation Expert Panels for Gene and Variant Curation | 000 | 1 | NIH | 4/18/2024 | $377,718 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI182369 | Elucidating structural and functional mechanisms of pyroptosis | 001 | 1 | NIH | 4/4/2024 | $0 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI182369 | Elucidating structural and functional mechanisms of pyroptosis | 000 | 1 | NIH | 3/8/2024 | $760,636 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K00DA060571 | Characterizing enhancers regulating transcription factor expression for cell-type specification across neurodevelopment | 000 | 3 | NIH | 2/1/2024 | $88,884 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DK139341 | Elucidation of the mechanisms by which fatty acids drive megakaryopoiesis | 000 | 1 | NIH | 4/10/2024 | $354,000 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21EY035902 | Elucidating synaptic motifs in the visual thalamus | 000 | 1 | NIH | 11/17/2023 | $221,250 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32NS134588 | Role of Choroid Plexus Autotaxin Secretion in Hemorrhage-Induced White Matter Injury | 000 | 1 | NIH | 1/12/2024 | $69,080 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99NS135123 | Development of Distinct Areas in the Human Cerebral Cortex | 000 | 1 | NIH | 1/12/2024 | $127,305 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32NS134588 | Role of Choroid Plexus Autotaxin Secretion in Hemorrhage-Induced White Matter Injury | 001 | 1 | NIH | 1/12/2024 | $0 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32NS136267 | Leveraging Choroid Plexus M-CSF Signaling to Prevent Inflammatory-Driven Hydrocephalus | 000 | 1 | NIH | 3/22/2024 | $72,000 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | F32NS136267 | Leveraging Choroid Plexus M-CSF Signaling to Prevent Inflammatory-Driven Hydrocephalus | 001 | 1 | NIH | 3/22/2024 | $0 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01NS134948 | Paradoxical Sensory Responses: A Clue Towards Understanding Biotypes in Autism Spectrum Disorder and Other Neurodevelopmental Disorders | 000 | 1 | NIH | 3/18/2024 | $510,609 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K99MH136290 | Genomic approaches to understand human neural specializations | 000 | 1 | NIH | 4/18/2024 | $127,305 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K08HL173561 | Endothelial cell-based therapy for pulmonary vascular disease using induced pluripotent stem cells | 000 | 1 | NIH | 4/19/2024 | $167,940 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI180137 | Mechanism of the transcription factor FoxP3 in regulatory T cell development | 000 | 1 | NIH | 12/6/2023 | $716,852 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL171206 | Mechanistic dissection of 22q11.2DS in zebrafish | 000 | 1 | NIH | 12/12/2023 | $559,111 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI178865 | Spatial, temporal, and functional study of the basal complex in Plasmodium falciparum | 000 | 1 | NIH | 3/18/2024 | $705,522 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | K23DK135822 | Intervening in Food Insecurity to Reduce and Mitigate (InFoRM) Childhood Obesity | 000 | 1 | NIH | 4/15/2024 | $195,781 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AR083424 | T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritis | 000 | 1 | NIH | 12/14/2023 | $492,123 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AR083424 | T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritis | 001 | 1 | NIH | 1/10/2024 | $0 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | UM1HL172702 | Pediatric Heart Network Clinical Research Centers - Boston Children's Hospital | 000 | 1 | NIH | 12/29/2023 | $497,813 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL167723 | Sphingolipid signaling in the endothelium during viral host defense | 000 | 1 | NIH | 12/20/2023 | $712,226 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | U01AI181964 | Consortium for food allergy research clinical center CoFar | 000 | 1 | NIH | 3/11/2024 | $380,000 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21CA283420 | Engineered exosome mimetics as targeted biological nanomedicines for pancreatic cancer | 000 | 1 | NIH | 2/21/2024 | $248,243 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21NS135389 | Mitigating Post-Traumatic Epileptogenesis by Enhancing Synaptic Glutamate Transport via Long-Term Non-Bactericidal Beta-Lactam Administration | 000 | 1 | NIH | 3/7/2024 | $221,250 |
| 2024 | 2024 | Children's Hospital Corporation, The | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | 90YE0303 | California Tribal Evaluation of Child Care and Development Fund Policies and Initiatives Implementation | 01 | 1 | ACF | 11/22/2023 | $300,000 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AG078423 | Shared Genetic and Environmental Influences on Age-Related Hearing Loss, Cognitive Decline, and Dementia Risk | 000 | 2 | NIH | 4/25/2024 | $745,397 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HG012871 | An ensemble framework for regulatory variant prediction. | 000 | 2 | NIH | 2/27/2024 | $508,990 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | UH3HL157564 | A Phase III Randomized Trial Comparing Unrelated Donor Bone Marrow Transplantation with Immune Suppressive Therapy for Newly Diagnosed Pediatric and Young Adult Patients with Severe Aplastic Anemia | 001 | 3 | NIH | 3/22/2024 | $636,067 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HD107060 | Inflammatory stressors in serotonergic brainstem dysfunction and SIDS | 000 | 2 | NIH | 3/19/2024 | $650,415 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01HL158192 | High resolution lineage tracing of developmental hematopoiesis | 000 | 2 | NIH | 2/12/2024 | $675,723 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R21EY033550 | Novel growth factors and regenerative RGC subtypes for optic nerve regeneration | 000 | 2 | NIH | 4/12/2024 | $221,250 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01AI177778 | Elucidating the functional mechanism of NLRP3 inflammasome activation | 000 | 2 | NIH | 2/21/2024 | $637,200 |
| 2024 | 2024 | CHILDREN'S HOSPITAL CORPORATION, THE | 300 LONGWOOD AVE | BOSTON | MA | 02115-5724 | SUFFOLK | USA | R01DK134647 | The Role of Tcf7l2 in maintaining liver zonation and metabolic homeostasis | 000 | 2 | NIH | 1/10/2024 | $423,613 |
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