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| Issue Date FY: 2024 ( Subtotal = $6,184,978 ) |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01DK128435 | The B Cell Insulin Receptor in Health and in Insulin Resistance | 000 | 3 | NIH | 12/5/2023 | $509,506 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | U01AI180158 | Cellular senescence and Associated Lysosomal Dysfunction in Immune Aging | 000 | 1 | NIH | 2/26/2024 | $692,640 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R13AG082490 | The Reproductive Aging Conference | 000 | 2 | NIH | 3/20/2024 | $49,000 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | RF1AG053268 | Molecular mechanisms underlying the preservation of neural stem cell quiescence during aging | 001 | 7 | NIH | 4/17/2024 | $1,120,249 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG075201 | Multidimensional mapping of proteome changes and mechanisms underlying yeast replicative aging | 000 | 3 | NIH | 4/22/2024 | $558,796 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01DK135807 | Novel components of mitochondrial regulation of insulin secretion in type 2 diabetes | 000 | 1 | NIH | 12/8/2023 | $670,313 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG072791 | Role of Selective Autophagy in Organismal Health | 000 | 3 | NIH | 4/24/2024 | $526,081 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | P30AG068345 | The University of Southern California and Buck Institute Nathan Shock Center | 001 | 4 | NIH | 3/26/2024 | $128,201 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG068025 | Geroscience metabolites beta-hydroxybutyrate and NAD+ linking inflammation and neuroenergetic failure in delirium | 000 | 4 | NIH | 10/26/2023 | $67,316 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG067325 | Neuronal FXR as a potential therapeutic target for Alzheimer's disease | 000 | 5 | NIH | 4/17/2024 | $625,485 |
| 2024 | 2024 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG067326 | Targeting Aging to prevent Alzheimer's Disease: the Geroscience Approach | 000 | 5 | NIH | 3/1/2024 | $523,687 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | UH3CA268105 | Evaluating diverse technologies for detecting and validating senescent cells in vivo | 001 | 3 | NIH | 3/20/2024 | $81,485 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | UH3CA268105 | Evaluating diverse technologies for detecting and validating senescent cells in vivo | 000 | 3 | NIH | 3/18/2024 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG081989 | A smart cell drug (SmaCD) delivery platform for mobile, targetable, and self-regulated combination therapy: a model project to rescue antibodies from Alzheimer's disease (AD) clinical trial failures | 000 | 2 | NIH | 1/15/2024 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | U54AG075932 | Senescent cell mapping, identification and validation for human somatic and reproductive tissues | 000 | 3 | NIH | 2/13/2024 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | P01AG066591 | Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias | 003 | 3 | NIH | 2/29/2024 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | P01AG066591 | Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias | 002 | 3 | NIH | 2/22/2024 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | P01AG066591 | Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias | 001 | 3 | NIH | 11/4/2023 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | P01AG066591 | Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias | 000 | 3 | NIH | 11/3/2023 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG073411 | Pioneer transcription factors in aging and neurodegeneration | 004 | 4 | NIH | 12/11/2023 | $417,484 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG073411 | Pioneer transcription factors in aging and neurodegeneration | 001 | 4 | NIH | 11/29/2023 | $366,825 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | P30AG068345 | The University of Southern California and Buck Institute Nathan Shock Center | 000 | 4 | NIH | 11/22/2023 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG068288 | Methylglyoxal drives astrocyte senescence to mediate neurodegeneration in Alzheimer's disease | 001 | 4 | NIH | 4/18/2024 | -$9,287 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | U01AG045844 | Caenorhabditis Intervention Testing Program - Buck Institute | 000 | 10 | NIH | 4/10/2024 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG038664 | Regulation of the Autophagy Pathway with Age and in Long-lived Animals | 000 | 12 | NIH | 11/30/2023 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | T32AG000266 | Training in Basic Research on Aging and Age-Related Disease | 001 | 25 | NIH | 12/1/2023 | $639,746 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | T32AG000266 | Training in Basic Research on Aging and Age-Related Disease | 003 | 25 | NIH | 2/21/2024 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | T32AG000266 | Training in Basic Research on Aging and Age-Related Disease | 002 | 25 | NIH | 2/1/2024 | $0 |
| 2024 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R56AG082819 | Investigating the interplay between hallmarks of aging; protein glycation, nutrient sensing, and senescence | 000 | 1 | NIH | 3/13/2024 | $0 |
| 2024 | 2022 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | T32AG000266 | Training in Basic Research on Aging and Age-Related Disease | 000 | 24 | NIH | 12/1/2023 | -$639,746 |
| 2024 | 2022 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R21AG077556 | Alternative folding of soluble proteins induced by A?42 and Tau in aged cells | 000 | 1 | NIH | 4/6/2024 | $0 |
| 2024 | 2022 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | UG3CA268105 | Evaluating diverse technologies for detecting and validating senescent cells in vivo | 000 | 2 | NIH | 3/20/2024 | -$81,485 |
| 2024 | 2022 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG068288 | Methylglyoxal drives astrocyte senescence to mediate neurodegeneration in Alzheimer's disease | 000 | 3 | NIH | 4/17/2024 | -$22,037 |
| 2024 | 2022 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | RF1AG062280 | New mechanistic insights into how the gut metabolite urolithin A extends lifespan and prevents AD | 000 | 1 | NIH | 2/20/2024 | $0 |
| 2024 | 2022 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | K01AG057862 | Synaptic mechanisms of tau-mediated pathogenesis in human iPSC-derived neurons | 000 | 5 | NIH | 12/4/2023 | -$32,600 |
| 2024 | 2021 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R21AG072663 | Targeting conserved diet-responsive transcriptional networks in neurons to slow neurodegeneration in Alzheimer's disease | 000 | 1 | NIH | 12/22/2023 | -$627 |
| 2024 | 2021 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | DP5OD024598 | Mechanism of organelle dysfunction during aging and the related rejuvenation process | 000 | 5 | NIH | 4/1/2024 | $0 |
| 2024 | 2021 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG057353 | Proteostasis and metabolism in brain aging | 000 | 5 | NIH | 1/11/2024 | $0 |
| 2024 | 2021 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R56AG070705 | Determining the role of OXR1 in aging and Alzheimer's disease | 000 | 1 | NIH | 3/8/2024 | $0 |
| 2024 | 2020 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01NS100529 | Identifying Factors Regulating Medium Spiny Neuron Differentiation or Maintenance as Therapeutic Targets for Huntington's Disease using Induced Pluripotent Stem Cells | 000 | 5 | NIH | 3/25/2024 | $0 |
| 2024 | 2020 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01DE026010 | Novel model for HIV Latency in Oral Primary Lymphoid Tissues | 000 | 6 | NIH | 11/29/2023 | $0 |
| 2024 | 2020 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01NS094422 | Genetic Correction of Mutant Huntingtin in Vivo | 000 | 5 | NIH | 3/25/2024 | -$6,053 |
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| Issue Date FY: 2023 ( Subtotal = $18,416,646 ) (Continued on the next page) |
| 2023 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | U01AG045844 | Caenorhabditis Intervention Testing Program - Buck Institute | 002 | 10 | NIH | 8/1/2023 | $719,371 |
| 2023 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R03OD036497 | Identification of blood biomarkers predictive of organ aging | 000 | 1 | NIH | 9/20/2023 | $1 |
| 2023 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R03OD036497 | Identification of blood biomarkers predictive of organ aging | 000 | 1 | NIH | 9/20/2023 | $387,999 |
| 2023 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG068025 | Geroscience metabolites beta-hydroxybutyrate and NAD+ linking inflammation and neuroenergetic failure in delirium | 002 | 4 | NIH | 4/27/2023 | $769,087 |
| 2023 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | R01AG081226 | TAKEOFF: Targeting Aging with Ketone Ester in Older adults for Function in Frailty | 000 | 1 | NIH | 8/16/2023 | $755,249 |
| 2023 | 2023 | BUCK INSTITUTE FOR RESEARCH ON AGING | 8001 REDWOOD BLVD | NOVATO | CA | 94945-1400 | MARIN | USA | UH3CA268105 | Evaluating diverse technologies for detecting and validating senescent cells in vivo | 000 | 3 | NIH | 8/28/2023 | $909,684 |
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