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| Issue Date FY: 2024 ( Subtotal = $20,375,984 ) (Continued on the next page) |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM118062 | Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics | 000 | 10 | NIH | 4/8/2024 | $571,690 |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R61CA278536 | Profiling and perturbing the inheritance of drug-induced metabolic states in cancer with Inheritance-Seq | 000 | 1 | NIH | 3/27/2024 | $207,092 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32AI179151 | Deep integration of multi-omics and patient health data to clarify risk factors of enterococcal infective endocarditis | 000 | 1 | NIH | 2/1/2024 | $71,810 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA287069 | A Chemoproteomic Approach to Identify Molecular Glues for Targeted Cancer Therapy | 000 | 1 | NIH | 2/1/2024 | $171,180 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS132022 | Biomarkers and mechanisms of PrP misfolding, mutation, and deficiency | 000 | 1 | NIH | 3/18/2024 | $678,020 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA279550 | Mechanisms promoting copper dependent cell death in cancer | 000 | 1 | NIH | 3/20/2024 | $31,002 |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3MH120096 | Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species. | 002 | 5 | NIH | 4/2/2024 | $136,480 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3MH120096 | Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species. | 001 | 5 | NIH | 2/6/2024 | $2,116,243 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3MH120096 | Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species. | 001 | 5 | NIH | 2/6/2024 | -$2,116,243 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UH3MH120096 | Development and validation of AAV vectors to manipulate specific neuronal subtypes and circuits involved in epilepsy and psychiatric disorders across mammalian species. | 000 | 5 | NIH | 11/20/2023 | $2,116,243 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00CA264422 | A visible machine learning system to discover targeted treatment solutions in cancer | 000 | 4 | NIH | 2/23/2024 | $95,948 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS131663 | Mechanism of Action of Prion Protein-Lowering Small Molecules | 000 | 2 | NIH | 3/15/2024 | $355,500 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K25AI168451 | Physical Biology and Deep Learning for Antibiotic Resistance and Discovery | 000 | 3 | NIH | 12/21/2023 | $125,706 |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL164811 | High-throughput cellular genetics to connect noncoding variants to coronary artery disease genes | 000 | 2 | NIH | 4/1/2024 | $635,621 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R00AG065516 | Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's disease | 000 | 4 | NIH | 11/15/2023 | $219,356 |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA276865 | Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment | 001 | 2 | NIH | 4/17/2024 | $55,091 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01CA276865 | Spatial genomic tools to interrogate T cell clonotypes, tumor clones and the microenvironment | 000 | 2 | NIH | 1/3/2024 | $609,545 |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R21CA269103 | Stitch-seq for genome-wide pooled genomic screening with RNA-seq readout | 001 | 3 | NIH | 4/17/2024 | $17,631 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R21CA269103 | Stitch-seq for genome-wide pooled genomic screening with RNA-seq readout | 000 | 3 | NIH | 3/5/2024 | $147,030 |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01AI172147 | Identification and Characterization of Microbial Metabolites in Immunity | 000 | 3 | NIH | 4/3/2024 | $786,407 |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 001 | 3 | NIH | 4/11/2024 | $37,382 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01NS125255 | How Substrate Dosage Drives Prion Disease Kinetics | 000 | 3 | NIH | 11/20/2023 | $480,630 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH129722 | 2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder | 000 | 3 | NIH | 1/3/2024 | $341,660 |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL157717 | Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS | 001 | 3 | NIH | 4/11/2024 | $38,570 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01HL157717 | Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS | 000 | 3 | NIH | 1/22/2024 | $861,010 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K00DK123834 | NBCe1-mediated Regulation of HCO3- is a Novel Mechanism Underlying Metabolic Reprogramming and Cystogenesis | 000 | 5 | NIH | 3/8/2024 | $93,982 |
| 2024 | 2024 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01HG011755 | Broad Institute Mendelian Genomic Research Center | 000 | 4 | NIH | 3/21/2024 | $2,247,946 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | K99CA277583 | AI-Powered Uncovering of Mechanisms in Cancer Through Causal Discovery Analysis and Generative Modeling of Heterogeneous Data | 000 | 2 | NIH | 2/9/2024 | $138,349 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2TR003437 | A Translator Knowledge Provider for Systems Chemical Biology | 001 | 1 | NIH | 1/13/2024 | $155,318 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2TR003433 | A Complex Disease Genetics Knowledge Provider for Biomedical Data Translator | 002 | 1 | NIH | 2/14/2024 | $0 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2TR003433 | A Complex Disease Genetics Knowledge Provider for Biomedical Data Translator | 003 | 1 | NIH | 2/16/2024 | $0 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2TR003433 | A Complex Disease Genetics Knowledge Provider for Biomedical Data Translator | 001 | 1 | NIH | 12/20/2023 | $1,050,680 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01EB031172 | Continuous Evolution of Proteins with Novel Therapeutic Potential | 000 | 4 | NIH | 1/11/2024 | $559,668 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01GM137606 | Chemical approaches for precision genome editing | 000 | 4 | NIH | 1/5/2024 | $326,369 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011450 | Enhancing gnomAD Sustainability: Implementing Site Reliability Engineering Principles for Genomic Data Infrastructure | 000 | 4 | NIH | 1/12/2024 | $2,321,100 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 002 | 4 | NIH | 3/12/2024 | $100,000 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 4 | NIH | 2/16/2024 | $270,000 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 4 | NIH | 2/16/2024 | $270,000 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U24HG011025 | The Global Alliance for Genomics and Health: Setting the Standards for Genomics and Health-Related Data Sharing | 001 | 4 | NIH | 2/16/2024 | $304,621 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | UM1DK105554 | The next iteration of the AMP-T2D Knowledge Portal | 000 | 9 | NIH | 1/24/2024 | $3,112,741 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | P41GM135019 | Center for Open Bioimage Analysis | 000 | 5 | NIH | 1/18/2024 | $1,136,551 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R35GM122547 | Advancing image-based profiling | 000 | 7 | NIH | 12/15/2023 | $573,066 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | F32CA271719 | Directed Clonal Evolution of Drug Resistant BRAF Mutant Melanoma for Cross-Sensitization to MAPK Hyperactivation | 000 | 1 | NIH | 12/26/2023 | $69,500 |
| 2024 | 2024 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK099465 | Mechanisms of disrupted homeostasis and kidney injury | 001 | 10 | NIH | 3/15/2024 | $565,177 |
| 2024 | 2023 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | OT2OD036440 | The Common Fund Knowledge Center (CFKC): providing scientifically valid knowledge from the Common Fund Data Ecosystem to a diverse biomedical research community. | 000 | 1 | NIH | 10/27/2023 | $0 |
| 2024 | 2023 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01MH132968 | 1/3 Akili: Phenotypic and genetic characterization of ADHD in Kenya and South Africa | 000 | 1 | NIH | 11/29/2023 | $0 |
| 2024 | 2023 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U19AI158076 | Attacking failure of antibiotic treatment by targeting antimicrobial resistance enabler cell-states | 000 | 2 | NIH | 2/23/2024 | $0 |
| 2024 | 2023 | THE BROAD INSTITUTE, INC | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | U01CA272612 | Translating novel cancer targets and mechanisms from the CTD^2 Network using molecular glues | 001 | 2 | NIH | 3/27/2024 | -$917,278 |
| 2024 | 2023 | BROAD INSTITUTE, INC., THE | 415 MAIN ST | CAMBRIDGE | MA | 02142-1027 | MIDDLESEX | USA | R01DK132299 | A functional genomics pipeline for genetic discovery in diabetic kidney disease | 000 | 2 | NIH | 12/20/2023 | $0 |
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