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| Issue Date FY: 2024 ( Subtotal = $33,329,578 ) (Continued on the next page) |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM133580 | Probing and Perturbing Transcriptional Condensates with Multiscale Modeling and Deep Learning | 000 | 6 | NIH | 4/3/2024 | $405,713 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EY029666 | Neural Mechanisms for Feature-Based Attention | 000 | 6 | NIH | 12/5/2023 | $555,564 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM124732 | Evolution and Regulation of Bacterial Proteome Composition | 000 | 7 | NIH | 1/4/2024 | $421,983 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM126982 | Metalloenzyme structure, function and assembly | 000 | 7 | NIH | 4/15/2024 | $369,312 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA218094 | Deep learning based antibody design using high-throughput affinity testing of synthetic sequences | 001 | 6 | NIH | 4/16/2024 | $21,980 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA218094 | Deep learning based antibody design using high-throughput affinity testing of synthetic sequences | 000 | 6 | NIH | 2/23/2024 | $395,659 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS119749 | A New Animal Model to Examine Nervous System Function Development and Regeneration | 001 | 4 | NIH | 4/9/2024 | $17,424 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R00NS119749 | A New Animal Model to Examine Nervous System Function Development and Regeneration | 000 | 4 | NIH | 3/20/2024 | $194,436 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R37CA273819 | Understanding the induction of T cell dysfunction in the context of lung cancer | 001 | 2 | NIH | 4/17/2024 | $26,499 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R37CA273819 | Understanding the induction of T cell dysfunction in the context of lung cancer | 000 | 2 | NIH | 3/7/2024 | $476,981 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DC020484 | Neural Mechanisms that Underlie Flexible Sensory Control of Behavioral States in C. elegans | 000 | 2 | NIH | 2/21/2024 | $343,340 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH133066 | Neuron-astrocyte mechanisms of norepinephrine in goal-directed learning | 000 | 2 | NIH | 2/15/2024 | $583,392 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI175489 | "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines | 000 | 2 | NIH | 1/31/2024 | $105,625 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AI175489 | "Extended dosing" immunization to enhance humoral immunity to next-generation vaccines | 000 | 2 | NIH | 1/31/2024 | $316,874 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM148220 | Protein Chemistry | 000 | 2 | NIH | 1/17/2024 | $427,375 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K99GM148718 | Cytotoxicity and function of incomplete proteins | 000 | 2 | NIH | 1/9/2024 | $123,971 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM148343 | Mechanisms and regulation of replication, the cell cycle, gene expression, and horizontal gene transfer in prokaryotes, focusing on Bacillus subtilis. | 000 | 2 | NIH | 12/5/2023 | $673,850 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01MH131715 | Layer-specific manipulation to test feedforward/feedback cortical circuitry | 000 | 2 | NIH | 11/28/2023 | $264,138 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG081017 | Single-cell multi-region dissection of AD-pathogen interactions for HSV-1 and CMV | 000 | 2 | NIH | 1/19/2024 | $677,551 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31NS127458 | Characterization of Dopamine Neuron Axonal Mitochondria Specialization and its Relevance to Parkinson?s Disease | 000 | 2 | NIH | 12/14/2023 | $47,694 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD110967 | Neurocognitive Foundations of Morphological Processing in Children with Dyslexia | 001 | 2 | NIH | 4/24/2024 | $4,784 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HD110967 | Neurocognitive Foundations of Morphological Processing in Children with Dyslexia | 000 | 2 | NIH | 1/23/2024 | $69,500 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U19AI167899 | Maternal Omics to Maximize Immunity | 000 | 3 | NIH | 3/19/2024 | $1,528,024 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | U19AI167899 | Maternal Omics to Maximize Immunity | 000 | 3 | NIH | 3/19/2024 | $825,959 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM145787 | Chemical Approaches to Studying the Mechanisms and Biophysical Properties of Complex Metallocofactors | 000 | 3 | NIH | 12/28/2023 | $275,405 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM146391 | Enantioselective Thioetherification of Olefins Guided by CuH Catalysis | 000 | 3 | NIH | 2/27/2024 | $69,500 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HL162564 | Nonviral delivery techniques for in vivo prime editing | 000 | 3 | NIH | 1/5/2024 | $387,750 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM144542 | Tools to determine and analyze the structures of molecular machines in motion | 000 | 3 | NIH | 3/21/2024 | $293,139 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM144115 | Tissue morphogenesis: From signals to forces | 000 | 3 | NIH | 12/12/2023 | $489,141 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01DA054584 | Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain | 000 | 3 | NIH | 2/13/2024 | $554,968 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01GM141275 | Selective Catalytic Strategies for Carbohydrate Synthesis | 000 | 3 | NIH | 1/8/2024 | $263,441 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01HL161069 | Personalized lesion modification optimizes atherosclerosis intervention | 000 | 3 | NIH | 12/20/2023 | $620,595 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB031992 | SMART BIOELECTRONIC IMPLANTS FOR CONTROLLED DELIVERY OF THERAPEUTIC PROTEINS IN VIVO AND ITS APPLICATION IN LONG-TERM TREATMENT OF HEMOPHILIA A | 000 | 3 | NIH | 1/23/2024 | $544,206 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA271243 | Intratumoral Cytokine Immunotherapy Studies in Companion Canine Cancer Models | 001 | 3 | NIH | 4/18/2024 | $25,511 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01CA271243 | Intratumoral Cytokine Immunotherapy Studies in Companion Canine Cancer Models | 000 | 3 | NIH | 3/14/2024 | $459,242 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS121073 | Analysis of Integrated Brain Functions Using Hemogenetic Imaging | 001 | 3 | NIH | 4/9/2024 | $38,065 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01NS121073 | Analysis of Integrated Brain Functions Using Hemogenetic Imaging | 000 | 3 | NIH | 1/25/2024 | $489,403 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB031813 | NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing | 000 | 3 | NIH | 2/1/2024 | $486,856 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32EY032756 | Visual cortex circuits mediating arousal and visual discrimination | 000 | 3 | NIH | 1/19/2024 | $76,272 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG069232 | Manipulating Neural Oscillations with Non-Invasive Sensory Stimulation for Alzheimer's Disease Intervention | 000 | 3 | NIH | 1/22/2024 | $633,958 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F31EY033996 | Elucidating the Role of Dorsal Lateral Geniculate Nucleus Burst-Mode Firing in Retinal Inactivation Induced Recovery from Monocular Deprivation | 000 | 3 | NIH | 3/12/2024 | $47,694 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32HG012307 | Connecting perturbations of RNA binding proteins to their consequences | 000 | 3 | NIH | 11/16/2023 | $73,772 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM145072 | Structure function investigations of radical transfer and disulfide exchange in a class Ia ribonucleotide reductase | 000 | 3 | NIH | 11/20/2023 | $71,792 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | F32GM143898 | Determinants of elongation rate differences between B. subtilis and E. coli RNA polymerases | 000 | 3 | NIH | 2/14/2024 | $2,500 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AT011460 | Noninvasive sensory stimulation to promote glymphatic-lymphatic clearance for the treatment of Alzheimer?s Disease | 000 | 4 | NIH | 4/12/2024 | $551,091 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01EB030946 | Synthetic gene sensors and effectors to redirect organoid development | 000 | 4 | NIH | 3/20/2024 | $578,545 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R35GM141963 | Development of New Strategies for Chemical Synthesis and Study of Complex Natural Products | 000 | 4 | NIH | 4/18/2024 | $663,643 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | K00CA264312 | Cellular engineering to improve the efficacy and specificity of targeted immunotherapy | 000 | 3 | NIH | 3/13/2024 | $89,489 |
| 2024 | 2024 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 77 MASSACHUSETTS AVE | CAMBRIDGE | MA | 02139-4301 | MIDDLESEX | USA | R01AG087374 | Lipid imaging expansion microscopy to study Alzheimer's disease | 000 | 1 | NIH | 4/23/2024 | $771,150 |
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