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District of Columbia Intellectual and Developmental Disabilities Research Center

Award Number: U54HD090257
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/22/2016
PERIOD OF PERFORMANCE END DATE: 05/31/2021

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District of Columbia Intellectual and Developmental Disabilities Research Center - Funded since 2001, the mission of the DC-IDDRC is to expand our understanding of the causes underlying intellectual and developmental disabilities (IDD), develop innovative therapies, and prevent or attenuate the full effects of these disorders, so that each child can achieve her/his full physical and intellectual potential. To realize this mission, we provide a rich environment for performing fully translational IDDR in the four collaborating DC academic medical centers (Children’s National Health System (lead), George Washington University, Howard University, and Georgetown University). In this proposal, our specific aims are: 1) To identify the causes and develop new clinical approaches for the prevention or amelioration of IDD; 2) To provide accessible, state-of-the-art and cost-effective core facilities for cohesive, multidisciplinary research and education/training in IDDR; 3) To create an intellectual home for investigators engaged in IDDR; and 4) To implement an innovative Research Project that addresses one of the five IDDR themes (Developing Biomarkers of Premature Brain Injury). The Director of the DC-IDDRC, Vittorio Gallo, PhD, is an internationally renowned neuroscientist who will continue to direct the Administrative Core that functions as the organizing nexus of the DC-IDDRC, providing management, administration, communication and training, assuring compliance and quality assurance, directing strategic planning and recruitment, and promoting the growth of the DC-IDDRC. The scientific cores provide an integrated platform and synergy for investigation as required by truly translational IDDR. The Clinical Translational Core (CTC) is designed to serve as a “one-stop-shop” for IDDR investigators, providing assistance at each stage of the clinical and translational research spectrum and optimizing the efficient, high quality implementation of fundamental research. The Genomics and Proteomics Core (GPC) provides advanced genomics and proteomics technologies, as well as specialized statistical analyses for DNA, mRNA and proteomics studies. The Cell and Tissue Microscopy Core (CTMC) supports investigators with a broad array of advanced cellular and molecular imaging tools for state-of-the-art neuroscience studies. The Human and Animal Imaging Core (HAIC) provides scientific and technical support for in vivo and ex vivo whole brain imaging, image processing, and image analysis for both human and animal studies. The Neurobehavioral Evaluation Core (NEC) provides sophisticated neurobehavioral and neuropsychological research support to define developmental and behavioral phenotypes in humans and animals. Our hypothesis-driven project is entitled “The vulnerable preterm cerebellum: Elucidating mechanisms and consequences of injury”. It utilizes the HAIC, NEC and CTC functions. Through these components, the DC-IDDRC will enhance the recruitment of investigators, generate innovation, and promote transdisciplinary research that together will facilitate the development, implementation, and dissemination of new diagnostic and therapeutic advances for the care of individuals with IDD.!


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$183,468 )
2022	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	5	12/7/2021	NON-COMPETING CONTINUATION	-$183,468
														Subtotal = -$183,468

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	5	1/12/2021	NON-COMPETING CONTINUATION	$0
2021	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	001	5	7/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,150,630 )
2020	2020	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	5	7/7/2020	NON-COMPETING CONTINUATION	$1,150,630
														Subtotal = $1,150,630

Issue Date FY: 2019 ( Subtotal = $1,143,856 )
2019	2019	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	001	4	8/16/2019	NON-COMPETING CONTINUATION	$1,143,856
2019	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	3	1/3/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,143,856

Issue Date FY: 2018 ( Subtotal = $1,150,409 )
2018	2018	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	3	7/23/2018	NON-COMPETING CONTINUATION	$1,150,409
														Subtotal = $1,150,409

Issue Date FY: 2017 ( Subtotal = $1,163,612 )
2017	2017	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	2	8/17/2017	NON-COMPETING CONTINUATION	$1,163,612
														Subtotal = $1,163,612

Issue Date FY: 2016 ( Subtotal = $1,259,053 )
2016	2016	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVENUE, NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Child Health and Human Development Extramural Research	000	1	9/21/2016	NEW	$1,259,053
														Subtotal = $1,259,053

Grand Total All Awards = $5,684,092

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District of Columbia Intellectual and Developmental Disabilities Research Center

Award Number: U54HD090257

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/22/2016

PERIOD OF PERFORMANCE END DATE: 05/31/2021

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