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Diagnosing the Unknown for Care and Advancing Science (DUCAS)

Award Number: U2CNS132415
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/19/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Diagnosing the Unknown for Care and Advancing Science (DUCAS) - PROJECT SUMMARY In our current healthcare system, it often takes years before patients with rare conditions and rare presentations of common conditions receive a diagnosis. In 2013, the National Institutes of Health supported the creation of the Undiagnosed Diseases Network (UDN) to address the needs of these patients, to facilitate the diagnostic process for those with undiagnosed conditions and generate new knowledge about underlying mechanisms of disease. The UDN was successful in solving medical mysteries, shortening diagnostic odysseys, and contributing to biomedical research discovery. In order to serve more patients, the UDN process must be scaled and integrated into broader healthcare and research ecosystems. As the Data Management Coordinating Center (DMCC) for a network of Diagnostic Centers of Excellence, Harvard Medical School will leverage experience in the UDN to create sustainable, nationally scaled infrastructure to support diagnosis, research, and care for those who are undiagnosed. This will be accomplished by bringing together experts in trans-institutional data sharing, data analysis, clinical care, bioinformatics, novel diagnostics, and translational research and creating three DMCC Cores - Administrative, Data Management, and Clinical Research Support - to address unmet needs of the undiagnosed. The Administrative Core will unite the DMCC and support activities of all three Cores. Together, the DMCC Cores will accomplish four aims: 1) Scale up UDN throughput by at least an order of magnitude to meet a pressing national need, 2) Leverage partnerships for sustainable coordination of diagnostic processes to increase patient autonomy while advancing opportunities for investigative science, 3) Maximize data mobility, interpretability, and shareability, and 4) Provide analytic service and data stewardship through the Data Management Core and Clinical Research Support Cores led by experts in genomics and AI teaming with clinicians and researchers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $4,240,252 )
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	9/1/2025	NON-COMPETING CONTINUATION	$0
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	3	9/18/2025	NON-COMPETING CONTINUATION	$0
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	4/15/2025	NON-COMPETING CONTINUATION	$4,240,252
														Subtotal = $4,240,252

Issue Date FY: 2024 ( Subtotal = $8,563,213 )
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	005	2	7/17/2024	NON-COMPETING CONTINUATION	$0
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/15/2024	NON-COMPETING CONTINUATION	$3,950,568
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	2	5/6/2024	NON-COMPETING CONTINUATION	$0
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	006	2	9/6/2024	NON-COMPETING CONTINUATION	$0
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	2	5/8/2024	NON-COMPETING CONTINUATION	$0
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	004	2	7/1/2024	SUPPLEMENT FOR EXPANSION	$4,173,694
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	4/8/2024	NON-COMPETING CONTINUATION	$438,951
														Subtotal = $8,563,213

Issue Date FY: 2023 ( Subtotal = $8,255,062 )
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	9/12/2023	SUPPLEMENT FOR EXPANSION	$3,550,000
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	003	1	9/15/2023	NEW	$0
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	8/16/2023	NEW	$0
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	4/19/2023	NEW	$4,705,062
														Subtotal = $8,255,062

Grand Total All Awards = $21,058,527

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Diagnosing the Unknown for Care and Advancing Science (DUCAS)

Award Number: U2CNS132415

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/19/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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