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California NeuroAIDS Tissue Network

Award Number: U24MH100928
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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California NeuroAIDS Tissue Network - ABSTRACT CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. The objectives of the CNTN remain the same today as it was when it was established in 1998 and encompass 1) recruitment, clinical assessment, and follow-up of a late-stage HIV cohort, and 2) collection, maintenance, and distribution of specimens to investigators interested in conducting research on the neuropathogenesis of HIV-induced central and peripheral nervous system dysfunction. This supplement is requested to cover the difference between CNTN’s minimal essential operations and operating in-full for the supplement period (03/01/2023 - 05/31/2023). Carryforward funds have been requested to cover minimal essential operations of the CNTN for this period, with many activities substantially diminished to reduce costs. CNTN will continue to maintain an in-life cohort of approximately 150 participants with the purpose of obtaining autopsies from high priority cases that are aligned with the thematic priorities of the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long-term HAART, and c) understanding comorbidities associated with HIV, including the effects of aging and chronic HIV-infection. CNTN will accumulate and manage a bank of in-life (plasma, CSF, blood) and autopsy (brain, heart, lung, liver, kidney, lymph node, blood, and CSF) specimens and data from persons living with HIV who are well characterized neuropsychologically, neuromedically, and psychiatrically. CNTN will collect tissues (e.g., gut lymphoid tissue, testes) for emerging CNS cure and eradication research. Unique within the NNTC, CNTN has assumed responsibility for CNS HIV-1 Antiretroviral Therapy Effects Research (CHARTER) specimens including plasma, CSF, buccal swabs, skin biopsies, and nucleic acids. De-identified CHARTER data (clinical, laboratory, genetic, neuroimaging, and research) have been transferred to the NNTC Data Coordinating Center (DCC), where they are now maintained. CNTN maintains both CNTN and CHARTER specimen resources. External requests for de-identified CNTN or CHARTER data or specimens are managed by the DCC in collaboration with NNTC sites, and the CNTN team is well equipped to provide timely distribution of both CNTN and CHARTER specimens according to NNTC data and resource distribution policies. Finally, CNTN continues to be an active collaborating member of the NNTC by: coordinating with the DCC and other NNTC sites; providing scientific and technical expertise to the wider research community as a voting member of the NNTC Steering Committee (SC), which reviews requests for data and specimens to facilitate neuroAIDS research; and as the leader of the NNTC Neuropsychology/Psychiatry subcommittee. Through the accomplishment of these objectives, the CNTN will continue to be a national and international resource serving the needs of neuroAIDS investigators.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$1,977 )
2024	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	10	7/12/2024	SUPPLEMENT FOR EXPANSION	-$1,977
														Subtotal = -$1,977

Issue Date FY: 2023 ( Subtotal = $553,251 )
2023	2023	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	002	10	6/23/2023	SUPPLEMENT FOR EXPANSION	$553,251
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	10	3/6/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	001	10	5/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $553,251

Issue Date FY: 2022 ( Subtotal = $1,382,733 )
2022	2022	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	10	2/9/2022	NON-COMPETING CONTINUATION	$1,382,733
														Subtotal = $1,382,733

Issue Date FY: 2021 ( Subtotal = $1,379,241 )
2021	2021	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	9	2/17/2021	NON-COMPETING CONTINUATION	$1,379,241
														Subtotal = $1,379,241

Issue Date FY: 2020 ( Subtotal = $1,533,367 )
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	001	8	3/10/2020	SUPPLEMENT FOR EXPANSION	$332,852
2020	2020	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	8	2/7/2020	NON-COMPETING CONTINUATION	$1,200,515
2020	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	003	6	9/3/2020	COMPETING CONTINUATION	$1,976
2020	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	002	5	9/3/2020	NON-COMPETING CONTINUATION	-$1,976
														Subtotal = $1,533,367

Issue Date FY: 2019 ( Subtotal = $1,197,215 )
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	002	7	8/8/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	003	7	8/26/2019	NON-COMPETING CONTINUATION	$0
2019	2019	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	001	7	2/13/2019	NON-COMPETING CONTINUATION	$1,197,215
2019	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	6	11/9/2018	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,197,215

Issue Date FY: 2018 ( Subtotal = $1,519,389 )
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	004	6	7/9/2018	COMPETING CONTINUATION	-$73,828
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	001	6	2/28/2018	COMPETING CONTINUATION	$1,200,515
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	003	6	7/5/2018	COMPETING CONTINUATION	$73,828
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	006	6	8/31/2018	SUPPLEMENT FOR EXPANSION	$392,702
2018	2018	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	005	6	8/9/2018	COMPETING CONTINUATION	$0
2018	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	002	5	7/5/2018	NON-COMPETING CONTINUATION	-$73,828
2018	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	5	2/26/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,519,389

Issue Date FY: 2017 ( Subtotal = $1,288,949 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	001	5	7/22/2017	NON-COMPETING CONTINUATION	$128,895
2017	2017	UNIVERSITY OF CALIFORNIA, SAN DIEGO	9500 GILMAN DR DEPT 621	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	5	2/28/2017	NON-COMPETING CONTINUATION	$1,160,054
														Subtotal = $1,288,949

Issue Date FY: 2016 ( Subtotal = $1,300,614 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	4	2/24/2016	EXTENSION WITH OR WITHOUT FUNDS	$1,300,614
														Subtotal = $1,300,614

Issue Date FY: 2015 ( Subtotal = $1,345,164 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	001	3	9/14/2015	SUPPLEMENT FOR EXPANSION	$163,027
2015	2015	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	3	4/30/2015	NON-COMPETING CONTINUATION	$1,182,137
														Subtotal = $1,345,164

Issue Date FY: 2014 ( Subtotal = $1,185,437 )
2014	2014	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	001	2	5/14/2014	NON-COMPETING CONTINUATION	$0
2014	2014	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	2	5/5/2014	NON-COMPETING CONTINUATION	$1,185,437
														Subtotal = $1,185,437

Issue Date FY: 2013 ( Subtotal = $1,195,887 )
2013	2013	UNIVERSITY OF CALIFORNIA-SAN DIEGO	9500 GILMAN DRIVE	LA JOLLA	CA	92093	SAN DIEGO	USA	Mental Health Research Grants	000	1	4/30/2013	NEW	$1,195,887
														Subtotal = $1,195,887

Grand Total All Awards = $13,879,270

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California NeuroAIDS Tissue Network

Award Number: U24MH100928

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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