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Biomarkers of Cognitive Decline Among Normal Individuals: The Biocard Cohort

Award Number: U19AG033655
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2009
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Biomarkers of Cognitive Decline Among Normal Individuals: The Biocard Cohort - PROJECT SUMMARY/ABSTRACT This is an Administrative Supplement for the grant entitled ‘Biomarkers of Cognitive Decline Among Normal Individuals: The BIOCARD Cohort’. The BIOCARD study is a longitudinal study begun in 1995 to examine the preclinical phase of Alzheimer’s disease (AD). All participants were cognitively normal at enrollment (n=349), and primarily middle age (mean age = 56.7 yrs.). The study was initially conducted at the NIH. In 2009, investigators at Johns Hopkins University (JHU) were funded to re-enroll the cohort and continue follow-up. Approximately 93% of the original cohort was re-enrolled at JHU and the duration of follow-up for many of the participants is now 30 years. Enrollment of an additional group of cognitively unimpaired individuals was initiated in 2020, with the goal of increasing the at-risk participants in the study. The total sample size is currently 466. The participants have been characterized longitudinally with comprehensive clinical and cognitive assessments and a wide range of AD biomarkers. Initially, the study procedures included cerebrospinal fluid (CSF) collection, blood draws and magnetic resonance imaging (MRI). As technology evolved over time, amyloid and tau positron emission tomography (PET) scans have been added to the biomarker procedures. A key strength of the study is the substantial number of individuals who have progressed from normal cognition to MCI (n=108). This makes it possible to examine the full ‘preclinical window’, including the years preceding amyloid positivity, as well as the years preceding tau positivity, and the subsequent onset of the symptomatic phase of AD. Thus, the study can address several overarching goals, including: (1) To examine proteomic changes measured in CSF and blood that precede amyloid positivity; (2) To examine novel spatially-specific MRI and Tau PET changes that precede tau positivity; (3) To examine the association between modifiable lifestyle factors and longitudinal proteomic and imaging measures with rate of decline in cognition; and (4) To examine the association of non-AD biomarkers and rate of decline in cognition among those who are AD biomarker positive, as well as those who are AD biomarker negative. It is essential to maintain this unique cohort to not only accomplish these goals, but to also provide a rich resource of cognitive, clinical and biomarker data for the field.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $985,616 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	001	15	8/13/2025	SUPPLEMENT FOR EXPANSION	$985,616
2025	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	15	7/28/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $985,616

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	004	15	7/8/2024	NON-COMPETING CONTINUATION	$0
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	002	15	5/9/2024	NON-COMPETING CONTINUATION	$0
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	15	1/16/2024	NON-COMPETING CONTINUATION	$0
2024	2023	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	003	15	5/24/2024	NON-COMPETING CONTINUATION	$0
2024	2022	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	001	14	5/9/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $5,018,550 )
2023	2023	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	002	15	7/10/2023	NON-COMPETING CONTINUATION	$5,018,550
2023	2019	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	001	11	4/26/2023	COMPETING CONTINUATION	$844,078
2023	2018	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	10	3/17/2023	NON-COMPETING CONTINUATION	-$844,078
														Subtotal = $5,018,550

Issue Date FY: 2022 ( Subtotal = $5,399,026 )
2022	2022	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	001	14	6/6/2022	NON-COMPETING CONTINUATION	$5,399,026
2022	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	13	3/22/2022	NON-COMPETING CONTINUATION	$0
2022	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	003	11	7/15/2022	COMPETING CONTINUATION	-$842,799
2022	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	002	10	7/15/2022	NON-COMPETING CONTINUATION	$842,799
														Subtotal = $5,399,026

Issue Date FY: 2021 ( Subtotal = $5,549,417 )
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	001	13	6/28/2021	SUPPLEMENT FOR EXPANSION	$407,980
2021	2021	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	13	5/20/2021	NON-COMPETING CONTINUATION	$5,141,437
														Subtotal = $5,549,417

Issue Date FY: 2020 ( Subtotal = $5,205,689 )
2020	2020	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	003	12	5/21/2020	NON-COMPETING CONTINUATION	$5,205,689
2020	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	002	11	4/21/2020	COMPETING CONTINUATION	$0
2020	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	001	11	4/14/2020	COMPETING CONTINUATION	$842,799
2020	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	10	4/14/2020	NON-COMPETING CONTINUATION	-$842,799
														Subtotal = $5,205,689

Issue Date FY: 2019 ( Subtotal = $4,979,715 )
2019	2019	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	002	11	8/27/2019	COMPETING CONTINUATION	$4,979,715
2019	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	10	1/24/2019	NON-COMPETING CONTINUATION	$0
2019	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	001	10	8/26/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $4,979,715

Issue Date FY: 2018 ( Subtotal = $2,923,791 )
2018	2018	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	10	4/14/2018	NON-COMPETING CONTINUATION	$2,923,791
														Subtotal = $2,923,791

Issue Date FY: 2017 ( Subtotal = $2,947,254 )
2017	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	001	9	6/22/2017	NON-COMPETING CONTINUATION	$294,726
2017	2017	JOHNS HOPKINS UNIVERSITY, THE	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	9	3/22/2017	NON-COMPETING CONTINUATION	$2,652,528
														Subtotal = $2,947,254

Issue Date FY: 2016 ( Subtotal = $2,984,023 )
2016	2016	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	8	3/29/2016	NON-COMPETING CONTINUATION	$2,984,023
														Subtotal = $2,984,023

Issue Date FY: 2015 ( Subtotal = $2,927,138 )
2015	2015	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	7	5/11/2015	NON-COMPETING CONTINUATION	$2,927,138
														Subtotal = $2,927,138

Issue Date FY: 2014 ( Subtotal = $3,091,209 )
2014	2014	JOHNS HOPKINS UNIVERSITY	CHARLES & 34TH STREETS	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	6	8/14/2014	COMPETING CONTINUATION	$3,091,209
														Subtotal = $3,091,209

Grand Total All Awards = $42,011,428

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Biomarkers of Cognitive Decline Among Normal Individuals: The Biocard Cohort

Award Number: U19AG033655

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2009

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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