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Understanding and Targeting the Pathophysiology of Youth-onset Type2 Diabetes

Award Number: U01DK134984
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/21/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2029

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Understanding and Targeting the Pathophysiology of Youth-onset Type2 Diabetes - The DISCOVERY study aims to extensively phenotype a large, diverse cohort of youth at risk for type 2 diabetes (T2D) as they transition through puberty, a critical window for the development of metabolic dysfunction. Through comprehensive biochemical, clinical, and psychosocial assessments, the study will track longitudinal changes in glycemia, insulin sensitivity, β-cell function, and behavioral and social determinants of health. By characterizing the pathophysiological trajectory of youth-onset T2D, DISCOVERY will help identify early indicators of disease progression and stratify youth according to risk. A robust biobank linked to rich phenotypic data will support in-depth analyses to inform the design of future precision prevention and intervention strategies. Input from local and central stakeholders will help guide study implementation and dissemination of findings.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	2/11/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $705,245 )
2025	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	2/17/2025	NON-COMPETING CONTINUATION	$705,245
2025	2024	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $705,245

Issue Date FY: 2024 ( Subtotal = $798,398 )
2024	2024	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	6/18/2024	NON-COMPETING CONTINUATION	$79,839
2024	2024	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/15/2024	NON-COMPETING CONTINUATION	$718,559
														Subtotal = $798,398

Issue Date FY: 2023 ( Subtotal = $65,301 )
2023	2023	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	2/24/2023	NEW	$0
2023	2023	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	2/21/2023	NEW	$65,301
														Subtotal = $65,301

Grand Total All Awards = $1,568,944

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Understanding and Targeting the Pathophysiology of Youth-onset Type2 Diabetes

Award Number: U01DK134984

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/21/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2029

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