Thursday, May 2, 2024
5/2/2024
Contact PD/PI: Powderly, William G. NRSA-Training-001 (075) J. NRSA Training Core (TL1), 7. Project Summary/Abstract Washington University School of Medicine has a robust research infrastructure, outstanding faculty mentors, well-developed clinical and translational research (CTR) training programs, and a large and diverse pool of excellent pre- and postdoctoral candidates. The objective of the TL1 is to ignite an interest in becoming a CTR scientist and provide the research experience, coursework, and career development opportunities to achieve this goal. Over the past 15 years, the TL1 has successfully trained predoctoral MD, PhD, and allied health doctoral students. For our last competitive renewal, we added postdoctoral trainees interested in entrepreneurship, technology transfer, and intellectual property development. We now propose to expand our program to add support for a mentored career development pathway for MD clinical fellows. We describe new innovative curricula in biomedical informatics, dissemination and implementation (D&I) science, community engagement, team science, health equity, and online initiatives. We will introduce new mentor training programs coordinated by the Clinical Research Training Center. We request annual funding for 5 predoctoral and 7 postdoctoral trainees for 1-2 years. The overall aims of the TL1 Program are: Aim 1: Enhance TL1 infrastructure and programs to provide outstanding clinical and translational research training opportunities for predoctoral and postdoctoral trainees. Aim 2: Develop competency-based, personalized learning opportunities for diverse trainees focused on conducting and integrating translational research in populations and across the lifespan. Aim 3: Engage diverse trainees, community stakeholders in multidisciplinary collaborative clinical and translational research to accelerate the benefit and impact of translational science. Aim 4: Provide high–quality comprehensive informatics training. Aim 5: Perform robust tracking and evaluation of TL1 program, trainees, and alumni, and use these data to improve the TL1 program. Trainees will engage in a mentored research experience with one of 74 experienced program faculty, complete CTR coursework, and engage in career development activities. This award period will focus on expanding training opportunities and increase recruitment of trainees from diverse backgrounds. The TL1 Program fills a critical niche at WUSM and our partners through its multidisciplinary focus on clinical and translational research, and unique emphasis on entrepreneurship, D&I, community engagement, and health equity. We will also work with the CTSA consortium to share curriculum, training, career development programs, and methods and tools to continually improve and provide outstanding CTR training in the future. Project Summary/Abstract Page 1517 Contact PD/PI: Powderly, William G. 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Daye D, Patel CB, Ahn J, Nguyen FT. Challenges and opportunities for reinvigorating the physician- scientist pipeline. J Clin Invest. 2015 Mar 2;125(3):883-7. PMCID: PMC4362227. 12. Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata R, Zaidi M. Training the physician-scientist: views from program directors and aspiring young investigators. JCI Insight. 2018 Dec 6;3(23). PMCID: PMC6328016. 13. Marsh JD, Todd RF, 3rd. Training and sustaining physician scientists: what is success? Am J Med. 2015 Apr;128(4):431-6. 14. Permar SR, Ward RA, Barrett KJ, Freel SA, Gbadegesin RA, Kontos CD, Hu PJ, Hartmann KE, Williams CS, Vyas JM. Addressing the physician-scientist pipeline: strategies to integrate research into clinical training programs. J Clin Invest. 2020 Mar 2;130(3):1058-1061. PMCID: PMC7269558. 15. Blish CA. Maintaining a Robust Pipeline of Future Physician-Scientists. J Infect Dis. 2018 Aug 14;218(suppl_1):S40-s43. PMCID: PMC6093428. 16. Titanji BK, Swartz TH. A Diverse Physician-Scientist Pipeline to Fight Structural Racism. Clin Infect Dis. 2020 Sep 14. 17. Luke DA, Sarli CC, Suiter AM, Carothers BJ, Combs TB, Allen JL, Beers CE, Evanoff BA. The Translational Science Benefits Model: A New Framework for Assessing the Health and Societal Benefits of Clinical and Translational Sciences. Clin Transl Sci. 2018 Jan;11(1):77-84. PMCID: PMC5759746. 18. https://news.stlpublicradio.org/health-science-environment/2017-08-31/seek-first-to-understand-lessons- on-poverty-teach-medical-students-to-be-better-doctors#stream/0. 19. https://www.teamscience.net/home. 20. Hesse BW. COALESCE (CTSA Online Assistance for Leveraging the Science of Collaborative Effort). JAMA. 2011;306(17):1925-1926. References Cited Page 1518
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