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Botanical Approaches to Combat Metabolic Syndrome

Award Number: T32AT004094
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/01/2009
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Botanical Approaches to Combat Metabolic Syndrome - Project Summary This application requests a second renewal for our Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (T32) entitled “Training in Botanical Approaches to Combat Metabolic Syndrome.” This training program is a collaborative effort between the Pennington Biomedical Research Center of Louisiana State University and the Departments of Plant Biology and Food Science at Rutgers University. The objective of this program is to train the highest caliber of postdoctoral fellows to become productive scientists integrating biomedical research methods and botanical discovery research with the capability of establishing successful scientific careers in academia, academic medicine, governmental agencies, and in the private sector. Metabolic syndrome is prevalent, poses a significant threat to public health, and it is characterized by the presence of co-existing traditional risk factors for cardiovascular disease (e.g. hypertension, dyslipidemia, glucose intolerance, obesity and insulin resistance). Preventative approaches for metabolic syndrome often primarily focus on lifestyle interventions. However, maintenance of lifestyle changes over time is poor. Thus, nutritional supplementation with botanicals that effectively address pathogenic mechanisms, combined with the acceptance and widespread use of supplements by the general public, present an attractive, novel and potentially effective approach to combat metabolic syndrome. Therefore, research training provided by this T32 will be directed toward evaluating the interactions between botanical characterization and the molecular, genetic, and physiologic approaches to achieve the ultimate goal of understanding how botanicals can contribute to health and normal tissue function. The program emphasizes hands on research training in an environment that encourages and facilitates transdisciplinary research and team science. The program will also benefit from the synergy and cutting-edge technologies of the NCCIH-sponsored Botanical Dietary Supplements Research Center (BDSRC) also focused on botanical supplements and metabolic syndrome. This integration between the T32 and the BDSRC provides trainees the opportunity to pursue studies with investigators whose interest span all organ systems impacted by obesity and metabolic syndrome. Since it began in 2009, this T32 program has graduated 15 postdocs who have remained in research-oriented careers and have acquired 30 grants (8 from NIH). Eleven graduates are now in academia and four are in industry. Seven postdocs are still in training. In total, this program’s 22 trainees have published 124 papers on their T32 projects including 66 first author papers. We are requesting 7 full-time postdoctoral trainee positions per year (5 at Pennington Biomedical and 2 at Rutgers) for the next five-year grant cycle (2020-2025). Trainees will be supported for two to three years. Each postdoctoral fellow will be encouraged to develop interdisciplinary research efforts to understand the effects of botanicals on components of metabolic syndrome.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $187,332 )
2024	2024	LSU PENNINGTON	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	15	5/13/2024	NON-COMPETING CONTINUATION	$187,332
														Subtotal = $187,332

Issue Date FY: 2023 ( Subtotal = $392,381 )
2023	2023	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	14	4/25/2023	NON-COMPETING CONTINUATION	$402,850
2023	2019	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	10	3/17/2023	NON-COMPETING CONTINUATION	-$10,469
														Subtotal = $392,381

Issue Date FY: 2022 ( Subtotal = $594,198 )
2022	2022	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	13	5/30/2022	NON-COMPETING CONTINUATION	$25
2022	2022	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	13	4/29/2022	NON-COMPETING CONTINUATION	$594,173
														Subtotal = $594,198

Issue Date FY: 2021 ( Subtotal = $537,713 )
2021	2021	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	002	12	4/29/2021	NON-COMPETING CONTINUATION	$537,713
2021	2020	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	11	12/2/2020	COMPETING CONTINUATION	$139,468
2021	2019	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	10	12/2/2020	NON-COMPETING CONTINUATION	-$139,468
														Subtotal = $537,713

Issue Date FY: 2020 ( Subtotal = $534,217 )
2020	2020	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	002	11	2/26/2020	COMPETING CONTINUATION	$534,217
2020	2019	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	10	11/7/2019	NON-COMPETING CONTINUATION	$0
2020	2019	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	10	11/6/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $534,217

Issue Date FY: 2019 ( Subtotal = $224,474 )
2019	2019	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	10	8/16/2019	NON-COMPETING CONTINUATION	$0
2019	2019	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	10	4/29/2019	NON-COMPETING CONTINUATION	$224,474
														Subtotal = $224,474

Issue Date FY: 2018 ( Subtotal = $297,764 )
2018	2018	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	9	5/12/2018	NON-COMPETING CONTINUATION	$14,882
2018	2018	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	9	4/16/2018	NON-COMPETING CONTINUATION	$282,882
														Subtotal = $297,764

Issue Date FY: 2017 ( Subtotal = $256,742 )
2017	2017	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	8	4/24/2017	NON-COMPETING CONTINUATION	$250,855
2017	2017	LOUISIANA STATE UNIVERSITY SYSTEM	6400 PERKINS RD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	7	2/9/2017	SUPPLEMENT FOR EXPANSION	$5,887
														Subtotal = $256,742

Issue Date FY: 2016 ( Subtotal = $464,945 )
2016	2016	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	7	5/3/2016	NON-COMPETING CONTINUATION	$464,945
														Subtotal = $464,945

Issue Date FY: 2015 ( Subtotal = $446,965 )
2015	2015	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	6	4/3/2015	COMPETING CONTINUATION	-$7,215
2015	2015	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	6	2/2/2015	COMPETING CONTINUATION	$454,180
														Subtotal = $446,965

Issue Date FY: 2013 ( Subtotal = $404,653 )
2013	2013	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	5	5/16/2013	NON-COMPETING CONTINUATION	$404,653
														Subtotal = $404,653

Issue Date FY: 2012 ( Subtotal = $274,927 )
2012	2012	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	4	5/24/2012	NON-COMPETING CONTINUATION	$274,927
														Subtotal = $274,927

Issue Date FY: 2011 ( Subtotal = $368,889 )
2011	2011	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	3	6/2/2011	NON-COMPETING CONTINUATION	$8,115
2011	2011	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	3	4/15/2011	NON-COMPETING CONTINUATION	$360,774
														Subtotal = $368,889

Issue Date FY: 2010 ( Subtotal = $390,726 )
2010	2010	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	2	5/14/2010	NON-COMPETING CONTINUATION	$3,097
2010	2010	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	2	4/27/2010	NON-COMPETING CONTINUATION	$387,629
														Subtotal = $390,726

Issue Date FY: 2009 ( Subtotal = $274,449 )
2009	2009	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	001	1	4/14/2009	NEW	$2,126
2009	2009	LOUISIANA ST UNIV, PENNINGTON BIOMEDICAL RES CTR	6400 PERKINS ROAD	BATON ROUGE	LA	70808	EAST BATON ROUGE	USA	Research and Training in Complementary and Integrative Health	000	1	3/12/2009	NEW	$272,323
														Subtotal = $274,449

Grand Total All Awards = $5,650,375

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Botanical Approaches to Combat Metabolic Syndrome

Award Number: T32AT004094

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/01/2009

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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