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Point-of-care system to assess the risk of trauma-induced acute respiratory distress syndrome

Award Number: R61HL167252
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Point-of-care system to assess the risk of trauma-induced acute respiratory distress syndrome - PROJECT SUMMARY/ABSTRACT Trauma-induced acute respiratory dysfunction syndrome (ARDS) is a deadly condition in which lung failure results from a traumatic injury to another part of the body. Recently, several studies have established a link between circulating histones and lung failure. Traumatic injuries cause a massive amount of cell death, resulting in the release of high concentrations of histones into circulation, which can directly lead to ARDS, as histones damage the lungs. In addition, circulating histones exacerbate exaggerated pro- and anti- inflammatory responses that also result in damage to the lungs and other organs. Identification and quantification of trauma-triggered circulating histones would provide an approach to assess the risk of ARDS, which could enable life-saving therapies before a patient develops ARDS. Diagnostic solutions to provide early detection of histones following trauma should be portable and rapid in order to assess the patient soon after the injury occurs. Currently, however, there are no portable and rapid approaches that enable detection of circulating histones to assess a trauma patient’s risk of developing ARDS. Our goal is to develop a diagnostic tool that is capable of quantitatively assessing the risk of trauma-induced ARDS at the point of care. This may include at the point of injury, in the transport vehicle to a trauma center, in the Emergency Department (ED), or in the operating room (OR). We have invented a Portable Histone Assay Technology (PHAST) that can quantify circulating histones directly from whole blood within 30 minutes. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $375,048 )
2024	2024	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BUILDING	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Lung Diseases Research	001	2	6/20/2024	NON-COMPETING CONTINUATION	$30,616
2024	2024	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BUILDING	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Lung Diseases Research	000	2	2/1/2024	NON-COMPETING CONTINUATION	$344,432
														Subtotal = $375,048

Issue Date FY: 2023 ( Subtotal = $392,776 )
2023	2023	UNIVERSITY OF MARYLAND, COLLEGE PARK	3112 LEE BLDG 7809 REGENTS DR	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Lung Diseases Research	000	1	2/28/2023	NEW	$392,776
														Subtotal = $392,776

Grand Total All Awards = $767,824

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Point-of-care system to assess the risk of trauma-induced acute respiratory distress syndrome

Award Number: R61HL167252

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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