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Using the PROMIS Cognition Item Bank for Early Detection of Cognitive Decline in Primary Care

Award Number: R61AG069776
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2024

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Using the PROMIS Cognition Item Bank for Early Detection of Cognitive Decline in Primary Care - Early diagnosis of Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) through detection of cognitive impairment (CI), especially at the mild stage, would support timely clinical intervention, recruitment of patients into clinical trials earlier in the disease trajectory and provide important information to initiate and guide care planning conversations with patients and their family members. One barrier to effective early identification of AD/ADRD is the lack of a brief, reliable, and validated screening tool that can be patient administered and is easily integrated into the EHR. Brief screeners for CI present an opportunity to increase early detection, but within the busy primary care setting, a screening tool must be fully EHR-integrated and preferably in a form that can be patient-administered (e.g., through a patient portal). We propose to validate an existing assessment of CI that would support universal screenings for AD/ADRD in older adults during primary care visits using an EHR-integrated brief screener in which patients self-report their cognitive abilities. The use of a patient-reported outcome (PRO) for the specific purpose of early detection of AD/ADRD is ideal in being both patient-centered and minimally burdensome while also providing useful ongoing data points that can alert the provider to subtle changes in cognitive function that may indicate a need for follow-up. The Patient Reported Outcome Measurement Information System (PROMIS) Cognitive Function (PCF) item bank contains 63 items that assess cognitive function. The PROMIS item banking approach has the benefits of being flexible, efficient, precise, and highly suitable for integration into electronic administration platforms, such as EHRs. The PCF items are accessible to those with low literacy, available in several languages, and have been tested for bias according to multiple demographic characteristics including race/ethnicity and age. These properties make the PCF item bank an ideal source for development of a screening tool to detect AD/ADRD among diverse populations in clinical settings. In the course of this five-year project, RAND and its partners (UPMC and NU) will conduct both qualitative and secondary data analysis to establish the validity of scores from the PCF item bank; use the resulting data to derive meaningful scoring criteria and interpretation guidance suitable for use in clinical practice; finalize the screener content; and work with at least two large regional health systems to implement the screener in their EHR and evaluate the feasibility and impact of having these data available during the clinical encounter via the EHR on primary care providers’ behaviors.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	THE RAND CORPORATION	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Aging Research	000	2	11/5/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	THE RAND CORPORATION	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Aging Research	000	2	6/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	RAND CORPORATION, THE	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Aging Research	001	2	4/4/2022	NON-COMPETING CONTINUATION	$0
2022	2021	RAND CORPORATION, THE	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Aging Research	000	2	2/16/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $715,018 )
2021	2021	RAND CORPORATION, THE	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Aging Research	002	2	7/7/2021	NON-COMPETING CONTINUATION	$715,018
2021	2020	RAND CORPORATION, THE	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Aging Research	000	1	11/20/2020	NEW	$0
2021	2020	RAND CORPORATION, THE	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Aging Research	001	1	1/26/2021	NEW	$0
														Subtotal = $715,018

Issue Date FY: 2020 ( Subtotal = $629,368 )
2020	2020	RAND CORPORATION, THE	1776 MAIN ST	SANTA MONICA	CA	90401	LOS ANGELES	USA	Aging Research	000	1	9/18/2020	NEW	$629,368
														Subtotal = $629,368

Grand Total All Awards = $1,344,386

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Using the PROMIS Cognition Item Bank for Early Detection of Cognitive Decline in Primary Care

Award Number: R61AG069776

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2024

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